The regulatory role of miRNA towards expressed genes in the pathogenesis of gout: A review

被引：0
作者：
Ashimi, Muhammad Harith Bin Nor [1 ]
Taib, Wan Rohani Wan [1 ]
Ismail, Imilia [1 ]
Mutalib, Nurul Syakima Ab [2 ]
Rahim, Siti Mariam [3 ]
机构：
[1] Univ Sultan Zainal Abidin, Fac Hlth Sci, Gong Badak Campus, Kuala Nerus 21300, Terengganu, Malaysia
[2] UKM Med Ctr, UKM Med Mol Biol Inst UMBI, Kuala Lumpur 56000, Malaysia
[3] Hosp Sultanah Nur Zahirah, Dept Med, Jalan Sultan Mahmud, Kuala Terengganu 20400, Terengganu, Malaysia
来源：
HUMAN GENE | 2023年 / 36卷
关键词：
Gout; Urate lowering therapy; mRNA and miRNA; SERUM URIC-ACID; GENOME-WIDE ASSOCIATION; URATE-ANION EXCHANGER; KIDNEY-DISEASE; ABCG2; GENE; HYPERURICEMIA; PREVALENCE; LOCI; RISK; IDENTIFICATION;
D O I：
10.1016/j.humgen.2023.201163
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Gout is inflammatory arthritis that affects joints with monosodium urate (MSU) crystal globally, often in men compared to women. Urate-related genes have been shown to play a role in the transportation and excretion of serum urate, affecting the level of uric acid and the development of gout. miRNA and mRNA have been known to regulate the function of immune and inflammatory response, thus influencing the onset or progression of diseases that include gouty arthritis. miRNA and mRNA also could help in the diagnosis and treatment in diseases. Therefore, this review summarizes the emerging evidence of the roles of mRNA and miRNA in development of gout as putative target biomarkers. GWAS have demonstrated 28 gene loci that relate to uric acid and the top three genes are SLC2A9, SLC22A12 and ABCG2. While miRNA plays a role in proliferation, apoptosis and other life processes which important in translation of mRNA gene expression. Some evidences demonstrated miR-146a target TRAF6, miR-155 target SHIP-1 and miR-34a target SLC22A12. Discovering expressed genes and miRNA related to gout or arthritis as potential biomarkers may help to understand their functions and may provide insights to overcome the intolerance to treatment based on personalized medicine.
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页数：6
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