A Review of CRISPR-Based Advances in Dermatological Diseases

被引：4
作者：
Lu, Xinyi [1 ]
Jin, Hongzhong [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Natl Clin Res Ctr Dermatol & Immunol Dis, Dept Dermatol,State Key Lab Complex Severe & Rare, Beijing 100730, Peoples R China
来源：
MOLECULAR DIAGNOSIS & THERAPY | 2023年 / 27卷 / 04期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
DYSTROPHIC EPIDERMOLYSIS-BULLOSA; HOMOLOGY-DIRECTED REPAIR; GENOMIC DNA; STEM-CELLS; KERATINOCYTES; REGENERATION; ACTIVATION; MUTATION; MODEL;
D O I：
10.1007/s40291-023-00642-5
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Clustered regularly interspaced short palindromic repeat (CRISPR) has revolutionized biomedical research by offering novel approaches to genetic and epigenetic manipulation. In dermatology, it has significantly promoted our understanding of complex diseases, and shown great potential in therapeutic applications. In this review, we introduce the adoption of CRISPR technology as a tool to study different types of skin disorders, including monogenic genodermatoses, inflammatory disorders, and cutaneous infections. We highlight the promising preclinical results of CRISPR-mediated treatment and important mechanic discoveries in investigative studies. Future opportunities and remaining challenges are also discussed. We predict that CRISPR will be more extensively used for dermatological research and even be accessible to patients in the future.
引用
收藏
页码：445 / 456
页数：12
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