Does Head Tremor Predict Postural Instability After Bilateral Thalamic Stimulation in Essential Tremor?

被引:1
作者
Shen, Jack [1 ]
Marsili, Luca [1 ]
Dwivedi, Alok K. [2 ]
Kuhlman, Gregory [1 ]
Duker, Andrew P. [1 ]
Espay, Alberto J. [1 ]
Mahajan, Abhimanyu [3 ]
机构
[1] Univ Cincinnati, Gardner Family Ctr Parkinsons Dis & Movement Diso, Dept Neurol & Rehabil Med, Cincinnati, OH USA
[2] Texas Tech Univ, Dept Mol & Translat Med, Div Biostat & Epidemiol, Hlth Sci Ctr, El Paso, TX USA
[3] Rush Univ, Med Ctr, Dept Neurol Sci, Rush Parkinsons Dis & Movement Disorders Program, Chicago, IL 60612 USA
基金
美国国家卫生研究院;
关键词
Essential tremor; Head tremor; Deep brain stimulation; Postural instability; Falls; BALANCE;
D O I
10.1007/s12311-022-01477-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Essential tremor (ET) may present with head tremor (HT), of presumed cerebellar nature. Deep brain stimulation (DBS) targeting the ventral intermediate (Vim) nucleus of the thalamus is a highly effective therapy for medication-refractory ET. However, stimulation-related side effects may include cerebellar abnormalities, such as postural instability. This retrospective cohort study evaluated the risk of post-Vim DBS postural instability (primary outcome measure) in patients with versus without head tremor (HT vs. nHT). The primary outcome measure, namely post-DBS postural instability, was assessed in both groups using a Wilcoxon rank sum t-test. The time to postural instability was determined using Cox proportional hazards regression analysis adjusted for age and sex. Out of 30 patients analyzed during the follow up period, there was similar postural instability detected in HT (9/14, 64%) and nHT patients (11/16, 69%) at 24 months post-Vim DBS (p=0.82), adjusted hazard ratio [aHR]=0.82, p=0.69). These data suggest that the presence or absence of HT does not have an impact on postural instability after bilateral Vim DBS in patients with ET.
引用
收藏
页码:1039 / 1044
页数:6
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