Euphorfinoids A and B, a pair of ent-atisane diterpenoid epimers from the roots of Euphorbia fischeriana, and their bioactivities

被引：3

作者：

Wei, Jiang-Chun ^{[1
]}

Gao, Yu-Ning ^{[1
]}

Huang, Hui-Hui ^{[1
]}

Zhang, Xiao-Yu ^{[1
]}

Liu, Xuan-Li ^{[1
]}

Gao, Xiao-Xu ^{[1
]}

Li, Na ^{[1
]}

Zhao, Yue ^{[1
]}

Wang, An-Hua ^{[1
]}

Jia, Jing-Ming ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Euphorbia fischeriana; ent-atisane; structure elucidation; biological activity; anti-proliferative; ANTI-ALZHEIMERS DISEASE; ABSOLUTE-CONFIGURATION; LATHYRANE DITERPENOIDS; ACETYLCHOLINESTERASE; ACHE;

D O I：

10.1080/14786419.2021.2003796

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Euphorfinoids A and B (1 and 2), a pair of ent-atisane diterpenoid epimers with a vicinal 2,3-diol moiety, together with four known analogues (3-6), were isolated from the roots of wild Euphorbia fischeriana. Their structures were elucidated by spectroscopic analysis, including extensive NMR, HR-ESIMS, NMR calculations, X-ray diffraction, and comparison with structurally related known analogues. Our bioassays have established that compound 1 displayed moderate anti-proliferative effects on Hcc1806 cell line with IC50 15.53 +/- 0.21 mu M, and compound 5 showed remarkable inhibitory effects against AChE with IC50 32.56 +/- 2.74 mu M by an in vitro screened experiment.

引用

页码：1300 / 1309

页数：10