Immune Cell Infiltration Types as Biomarkers for the Recurrence Diagnosis and Prognosis of Bladder Cancer

被引：2

作者：

Xu, Hongwei ^{[1
]}

Sun, Dapeng ^{[1
]}

Zhou, Dahong ^{[1
]}

Sun, Shiheng ^{[1
,2
]}

机构：

[1] Heilongjiang Prov Hosp, Dept Geriatr Neurol, Harbin, Heilongjiang, Peoples R China

[2] Heilongjiang Prov Hosp, Urol Dept, No 82 zhongshan Rd, Harbin, Heilongjiang, Peoples R China

来源：

CANCER INVESTIGATION | 2024年 / 42卷 / 02期

关键词：

Bladder cancer; recurrence; immune infiltration; prognostic model; ONCOLOGIC OUTCOMES; EXPRESSION; RISK; SURVIVAL; PREDICTION; CARCINOMA; INNATE; PD-L1;

D O I：

10.1080/07357907.2024.2308161

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study aimed to investigate the role of infiltrating immune cell types in diagnosing and predicting bladder cancer recurrence. This study mainly applied some algorithms, including Estimate the Proportion of Immune and Cancer Cells (EPIC), support vector machine-recursive feature elimination (SVM-RFE), random forest out-of-bag (RF-OOB) and least absolute shrinkage and selection operator (LASSO)-Cox regression analysis. We found six immune infiltrating cell types significantly associated with recurrence prognosis and two independent clinical prognostic factors. Infiltrating immune cell types (IICTs) based on the prognostic immune risk score (pIRS) models may provide significant biomarkers for the diagnosis and prognostic prediction of bladder cancer recurrence.

引用

页码：186 / 198

页数：13

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