Downregulation of complement factor H attenuates the stemness of MDA-MB-231 breast cancer cells via modulation of the ERK and p38 signaling pathways
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作者:
Park, Soon Yong
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Dongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South KoreaDongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South Korea
Park, Soon Yong
[1
]
Eum, Da-Young
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Dongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South KoreaDongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South Korea
Eum, Da-Young
[1
]
Jin, Yunho
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Dongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South KoreaDongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South Korea
Jin, Yunho
[1
]
Lee, Chae Young
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Dongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South KoreaDongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South Korea
Lee, Chae Young
[1
]
Shim, Jae Woong
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Dongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South KoreaDongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South Korea
Shim, Jae Woong
[1
]
Choi, Si Ho
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Dongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South KoreaDongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South Korea
Choi, Si Ho
[1
]
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Park, Seong-Joon
[1
]
Heo, Kyu
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Dongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South KoreaDongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South Korea
Heo, Kyu
[1
]
Choi, Yoo Jin
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Dongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South KoreaDongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South Korea
Choi, Yoo Jin
[1
]
机构:
[1] Dongnam Inst Radiol & Med Sci, Res Dept Oncol, 40 Jwadong Gil, Busan 460333, South Korea
The complement system is a powerful innate immune system deployed in the immediate response to pathogens and cancer cells. Complement factor H (CFH), one of the regulators involved in the complement cascade, can interrupt the death of target cells. Certain types of cancer, such as breast cancer, can adopt an aggressive phenotype, such as breast cancer stem cells (BCSCs), through enhancement of the defense system against complement attack by amplifying various complement regulators. However, little is known about the association between CFH and BCSCs. In the present study, the roles of CFH in the CSC characteristics and radioresistance of MDA-MB-231 human breast cancer cells were investigated. CFH knockdown in MDA-MB-231 cells decreased the viability of the cells upon complement cascade activation. Notably, CFH knockdown also decreased cell survival and suppressed mammosphere formation, cell migration and cell invasion by attenuating radioresistance. Additionally, CFH knockdown further enhanced irradiation-induced apoptosis through G2/M cell cycle arrest. It was also discovered that CFH knockdown attenuated the aggressive phenotypes of cancer cells by regulating CSC-associated gene expression. Finally, by microarray analysis, it was found that the expression of erythrocyte membrane protein band 4.1-like 3 (EPB41L3) was markedly increased following CFH knockdown. EPB41L3 inhibited ERK and activated the p38 MAPK signaling pathway. Taken together, these results indicated that CFH knockdown attenuated CSC properties and radioresistance in human breast cancer cells via controlling MAPK signaling and through upregulation of the tumor suppressor, EPB41L3.
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St George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
UNSW Sydney, Fac Med, St George & Sutherland Clin Sch, Kensington, NSW 2052, AustraliaSt George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
Bai, Xupeng
Ni, Jie
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St George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
UNSW Sydney, Fac Med, St George & Sutherland Clin Sch, Kensington, NSW 2052, AustraliaSt George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
Ni, Jie
Beretov, Julia
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St George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
UNSW Sydney, Fac Med, St George & Sutherland Clin Sch, Kensington, NSW 2052, Australia
St George Hosp, NSW Hlth Pathol, Anat Pathol, Kogarah, NSW 2217, AustraliaSt George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
Beretov, Julia
Graham, Peter
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St George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
UNSW Sydney, Fac Med, St George & Sutherland Clin Sch, Kensington, NSW 2052, AustraliaSt George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
Graham, Peter
Li, Yong
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h-index: 0
机构:
St George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
UNSW Sydney, Fac Med, St George & Sutherland Clin Sch, Kensington, NSW 2052, Australia
Zhengzhou Univ, Sch Basic Med Sci, Zhengzhou 450001, Henan, Peoples R ChinaSt George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
机构:
St George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
UNSW Sydney, Fac Med, St George & Sutherland Clin Sch, Kensington, NSW 2052, AustraliaSt George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
Bai, Xupeng
Ni, Jie
论文数: 0引用数: 0
h-index: 0
机构:
St George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
UNSW Sydney, Fac Med, St George & Sutherland Clin Sch, Kensington, NSW 2052, AustraliaSt George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
Ni, Jie
Beretov, Julia
论文数: 0引用数: 0
h-index: 0
机构:
St George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
UNSW Sydney, Fac Med, St George & Sutherland Clin Sch, Kensington, NSW 2052, Australia
St George Hosp, NSW Hlth Pathol, Anat Pathol, Kogarah, NSW 2217, AustraliaSt George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
Beretov, Julia
Graham, Peter
论文数: 0引用数: 0
h-index: 0
机构:
St George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
UNSW Sydney, Fac Med, St George & Sutherland Clin Sch, Kensington, NSW 2052, AustraliaSt George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
Graham, Peter
Li, Yong
论文数: 0引用数: 0
h-index: 0
机构:
St George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia
UNSW Sydney, Fac Med, St George & Sutherland Clin Sch, Kensington, NSW 2052, Australia
Zhengzhou Univ, Sch Basic Med Sci, Zhengzhou 450001, Henan, Peoples R ChinaSt George Hosp, Canc Care Ctr, Kogarah, NSW 2217, Australia