Prognostic Value of Mandard's Tumor Regression Grade (TRG) in Post Chemo-Radiotherapy Cervical Cancer

被引：2

作者：

Scaglione, Giulia ^{[1
]}

Arciuolo, Damiano ^{[1
]}

Travaglino, Antonio ^{[1
,2
]}

Santoro, Angela ^{[1
]}

Angelico, Giuseppe ^{[3
]}

Spadola, Saveria ^{[3
]}

Inzani, Frediano ^{[4
]}

D'Alessandris, Nicoletta ^{[1
]}

Raffone, Antonio ^{[5
]}

Fulgione, Caterina ^{[6
]}

Urtueta, Belen Padial ^{[1
]}

Sfregola, Stefania ^{[1
]}

Valente, Michele ^{[1
]}

Addante, Francesca ^{[1
]}

d'Amati, Antonio ^{[7
]}

Cianfrini, Federica ^{[1
]}

Piermattei, Alessia ^{[1
]}

Anchora, Luigi Pedone ^{[8
]}

Scambia, Giovanni ^{[8
]}

Ferrandina, Gabriella ^{[8
]}

Zannoni, Gian Franco ^{[1
]}

机构：

[1] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Woman & Childs Hlth & Publ Hlth Sci, Gynecopathol & Breast Pathol Unit, I-00168 Rome, Italy

[2] Univ Insubria, Dept Med & Technol Innovat, Pathol Unit, I-21100 Varese, Italy

[3] Cannizzaro Hosp, Pathol Unit, I-95126 Catania, Italy

[4] Univ Pavia, Dept Mol Med, Anat Pathol Unit, I-27100 Pavia, Italy

[5] Univ Bologna, Dept Med & Surg Sci DIMEC, I-40126 Bologna, Italy

[6] Federico II Univ Naples, Dept Neurosci Reprod Sci & Dent, Gynecol & Obstet Unit, I-80131 Naples, Italy

[7] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area DiMePRe, I-70100 Bari, Italy

[8] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Woman & Childs Hlth & Publ Hlth Sci, Gynecol Oncol Unit, I-00168 Rome, Italy

来源：

DIAGNOSTICS | 2023年 / 13卷 / 20期

关键词：

locally advanced cervical cancer; Mandard scoring system; prognostic stratification; SQUAMOUS-CELL CARCINOMA; LYMPHOVASCULAR SPACE INVASION; NEOADJUVANT CHEMOTHERAPY; PATHOLOGICAL-RESPONSE; UTERINE CERVIX; ADENOCARCINOMA; ESOPHAGEAL; SURGERY; RADIOCHEMOTHERAPY; CHEMORADIATION;

D O I：

10.3390/diagnostics13203228

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In locally advanced cervical cancer (LACC), definitive chemo-radiotherapy is the standard treatment, but chemo-radiotherapy followed by surgery could be an alternative choice in selected patients. We enrolled 244 patients affected by LACC and treated with CT-RT followed by surgery in order to assess the prognostic role of the histological response using the Mandard scoring system. Results: A complete pathological response (TRG 0) was observed in 118 patients (48.4%), rare residual cancer cells (TRG2) were found in 49 cases (20.1%), increased number of cancer cells but fibrosis still predominating (TRG3) in 35 cases (14.3%), and 42 (17.2%) were classified as non-responders (TRG4-5). TRG was significantly associated with both OS (p < 0.001) and PFS (p < 0.001). The survival curves highlighted two main prognostic groups: TRG1-TRG2 and TRG3-TRG4-5. Main responders (TRG1-2) showed a 92% 5-year overall survival (5y-OS) and a 75% 5-year disease free survival (5y-DFS). Minor or no responders showed a 48% 5y-OS and a 39% 5y-DFS. The two-tiered TRG was independently associated with both DFS and OS in Cox regression analysis. Conclusion. We showed that Mandard TRG is an independent prognostic factor in post-CT/RT LACC, with potential benefits in defining post-treatment adjuvant therapy.

引用

页数：13

共 62 条

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