Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships

被引：6
作者：
Li, Shaochen [1 ,2 ]
Lv, Min [2 ]
Xu, Hui [1 ,2 ]
机构：
[1] Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China
[2] Northwest A&F Univ, Coll Plant Protect, Yangling 712100, Shaanxi, Peoples R China
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2023年 / 23卷 / 08期
关键词：
Piperine; biological activity; mechanism of action; total synthesis; structural modification; structure-activity relationship; NF-KAPPA-B; BLACK PEPPER; BIOLOGICAL EVALUATION; IN-VITRO; ANTIINFLAMMATORY ACTIVITY; INHIBITS PROLIFERATION; ULCERATIVE-COLITIS; ACID-AMIDES; CURCUMIN; DERIVATIVES;
D O I：
10.2174/1389557522666220726121012
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Natural products are an invaluable source for the discovery of drug and pesticide candidates. Piperine, a simple and pungent alkaloid, is isolated from several plants of Piperaceae. Piperine and its derivatives displayed a wide range of biological properties, such as antitumor activity, anti-inflammatory activity, antioxidant activity, neuroprotective activity, insecticidal activity, etc. In recent years, lots of works focused on the biological activities, mechanisms of action, total synthesis, and structural modifications of piperine and its derivatives have been conducted. To the best of our knowledge, however, few review articles related to the biological activities, mechanisms of action, total synthesis, and structural modifications of piperine and its derivatives have been reported to date. Therefore, this review summarizes the research advances (from 2014 to 2020) of piperine and its derivatives regarding bioactivity, mechanisms of action, total synthesis, and structural modifications. Meanwhile, the structure-activity relationships of piperine and its derivatives are also discussed.
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收藏
页码：917 / 940
页数：24
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