Research progress on specific and non-specific immune effects of BCG and the possibility of BCG protection against COVID-19

被引：8

作者：

Du, Jingli ^{[1
]}

Su, Yue ^{[1
]}

Wang, Ruilan ^{[1
]}

Dong, Enjun ^{[1
]}

Cao, Yan ^{[1
]}

Zhao, Wenjuan ^{[1
]}

Gong, Wenping ^{[1
]}

机构：

[1] Peoples Liberat Army Gen Hosp, Med Ctr 8, TB Prevent & Control Key Lab, Beijing Key Lab New Tech TB Diag & Treatment,Senio, Beijing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

Bacille Calmette-Guerin (BCG); COVID-19; specific and non-specific immunity; tuberculosis (TB); trained immunity; MYCOBACTERIUM-TUBERCULOSIS INFECTION; BACILLE CALMETTE; TRAINED IMMUNITY; VACCINATION; MORTALITY; CELLS; REVACCINATION; MACROPHAGES; ASSOCIATION; CHILDREN;

D O I：

10.3389/fimmu.2023.1118378

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacille Calmette-Guerin (BCG) is the only approved vaccine for tuberculosis (TB) prevention worldwide. BCG has an excellent protective effect on miliary tuberculosis and tuberculous meningitis in children or infants. Interestingly, a growing number of studies have shown that BCG vaccination can induce nonspecific and specific immunity to fight against other respiratory disease pathogens, including SARS-CoV-2. The continuous emergence of variants of SARS-CoV-2 makes the protective efficiency of COVID-19-specific vaccines an unprecedented challenge. Therefore, it has been hypothesized that BCG-induced trained immunity might protect against COVID-19 infection. This study comprehensively described BCG-induced nonspecific and specific immunity and the mechanism of trained immunity. In addition, this study also reviewed the research on BCG revaccination to prevent TB, the impact of BCG on other non-tuberculous diseases, and the clinical trials of BCG to prevent COVID-19 infection. These data will provide new evidence to confirm the hypotheses mentioned above.

引用

页数：13

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