Successful treatment with tofacitinib for relapse of rapidly progressive interstitial lung disease in anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis

被引：8

作者：

Hama, Satoshi ^{[1
]}

Akiyama, Mitsuhiro ^{[1
,2
]}

Higashida-Konishi, Misako ^{[1
]}

Oshige, Tatsuhiro ^{[1
]}

Takei, Hiroshi ^{[1
,2
]}

Izumi, Keisuke ^{[1
,2
]}

Oshima, Hisaji ^{[1
]}

Okano, Yutaka ^{[1
]}

机构：

[1] Natl Hosp Org, Dept Med, Tokyo Med Ctr, Div Rheumatol, Tokyo, Japan

[2] Keio Univ, Dept Internal Med, Sch Med, Div Rheumatol, Tokyo, Japan

来源：

MODERN RHEUMATOLOGY CASE REPORTS | 2023年 / 7卷 / 01期

关键词：

Tofacitinib; Janus kinase inhibitor; interstitial lung disease; dermatomyositis; anti-melanoma differentiation-associated gene 5 antibody; RHEUMATOLOGY CLASSIFICATION CRITERIA; IDIOPATHIC INFLAMMATORY MYOPATHIES; 2017 EUROPEAN LEAGUE; RHEUMATISM/AMERICAN COLLEGE; ADULT; PNEUMONIA; PROGNOSIS; THERAPY;

D O I：

10.1093/mrcr/rxac049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anti-melanoma differentiation-associated gene 5 (MDA5) antibody is associated with clinically amyopathic dermatomyositis (CADM) with rapidly progressive interstitial lung disease (RP-ILD). Recently, several studies have reported that tofacitinib (TOF), a Janus kinase inhibitor, might be effective for cases of new or refractory RP-ILD in anti-MDA5 antibody-positive CADM; however, it is unknown whether TOF can also be effective for relapsed cases. We herein report a relapsed case of RP-ILD in anti-MDA5 antibody-positive CADM, which was successfully treated by combination therapy with TOF (5 mg twice daily). Our case suggests that TOF may also be a potential treatment option for relapsed cases of this disease.

引用

页码：92 / 95

页数：4

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