The NLRP3 inflammasome: a vital player in inflammation and mediating the anti-inflammatory effect of CBD
被引:12
作者:
Chu, Feng-xin
论文数: 0引用数: 0
h-index: 0
机构:
China Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
Chu, Feng-xin
[1
,2
]
Wang, Xiao
论文数: 0引用数: 0
h-index: 0
机构:
China Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
Wang, Xiao
[1
,2
]
Li, Bo
论文数: 0引用数: 0
h-index: 0
机构:
China Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
Li, Bo
[1
,2
]
Xu, Li-li
论文数: 0引用数: 0
h-index: 0
机构:
China Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
Xu, Li-li
[1
,2
]
Di, Bin
论文数: 0引用数: 0
h-index: 0
机构:
China Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
Di, Bin
[1
,2
]
机构:
[1] China Pharmaceut Univ, Off China Natl Narcot Control Commiss, Joint Lab Key Technol Narcot Control, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R China
BackgroundThe NLRP3 inflammasome is a vital player in the emergence of inflammation. The priming and activation of the NLRP3 inflammasome is a major trigger for inflammation which is a defense response against adverse stimuli. However, the excessive activation of the NLRP3 inflammasome can lead to the development of various inflammatory diseases. Cannabidiol, as the second-most abundant component in cannabis, has a variety of pharmacological properties, particularly anti-inflammation. Unlike tetrahydrocannabinol, cannabidiol has a lower affinity for cannabinoid receptors, which may be the reason why it is not psychoactive. Notably, the mechanism by which cannabidiol exerts its anti-inflammatory effect is still unclear.MethodsWe have performed a literature review based on published original and review articles encompassing the NLRP3 inflammasome and cannabidiol in inflammation from central databases, including PubMed and Web of Science.Results and conclusionsIn this review, we first summarize the composition and activation process of the NLRP3 inflammasome. Then, we list possible molecular mechanisms of action of cannabidiol. Next, we explain the role of the NLRP3 inflammasome and the anti-inflammatory effect of cannabidiol in inflammatory disorders. Finally, we emphasize the capacity of cannabidiol to suppress inflammation by blocking the NLRP3 signaling pathway, which indicates that cannabidiol is a quite promising anti-inflammatory compound.
引用
收藏
页码:227 / 242
页数:16
相关论文
共 181 条
[61]
Hampson AJ, 2000, ANN NY ACAD SCI, V899, P274, DOI 10.1111/j.1749-6632.2000.tb06193.x
机构:
Univ Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
Hartmann, Alice
Vila-Verde, Carla
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
Vila-Verde, Carla
Guimaraes, Francisco S. S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
Guimaraes, Francisco S. S.
Joca, Samia R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, Brazil
Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto FCFRP, BioMol Sci Dept, Ribeirao Preto, Brazil
Aarhus Univ, Dept Biomed, Aarhus, DenmarkUniv Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
Joca, Samia R.
Lisboa, Sabrina F. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, Brazil
Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto FCFRP, BioMol Sci Dept, Ribeirao Preto, Brazil
Univ Sao Paulo FCFRP USP, Sch Pharmaceut Sci Ribeirao Preto, Biomol Sci Dept, Av Cafe S-N, BR-14049903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
机构:
Univ Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USAUniv Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USA
Hayashi, Kazuhiro
Lesnak, Joseph B. B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USAUniv Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USA
Lesnak, Joseph B. B.
Plumb, Ashley N. N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USAUniv Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USA
Plumb, Ashley N. N.
Rasmussen, Lynn A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USAUniv Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USA
Rasmussen, Lynn A. A.
Sluka, Kathleen A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USAUniv Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USA
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
He, Yuan
Hara, Hideki
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Hara, Hideki
Nunez, Gabriel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
He, Yuan
Zeng, Melody Y.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Zeng, Melody Y.
Yang, Dahai
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R ChinaUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Yang, Dahai
Metro, Benny
论文数: 0引用数: 0
h-index: 0
机构:
Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, IsraelUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Metro, Benny
Nunez, Gabriel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
机构:
Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USAUniv Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USA
Hoffman, HM
Mueller, JL
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USA
Mueller, JL
Broide, DH
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USA
Broide, DH
Wanderer, AA
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USA
Wanderer, AA
Kolodner, RD
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USA
机构:
Univ Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
Hartmann, Alice
Vila-Verde, Carla
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
Vila-Verde, Carla
Guimaraes, Francisco S. S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
Guimaraes, Francisco S. S.
Joca, Samia R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, Brazil
Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto FCFRP, BioMol Sci Dept, Ribeirao Preto, Brazil
Aarhus Univ, Dept Biomed, Aarhus, DenmarkUniv Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
Joca, Samia R.
Lisboa, Sabrina F. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, Brazil
Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto FCFRP, BioMol Sci Dept, Ribeirao Preto, Brazil
Univ Sao Paulo FCFRP USP, Sch Pharmaceut Sci Ribeirao Preto, Biomol Sci Dept, Av Cafe S-N, BR-14049903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Sch Med Ribeirao Preto FMRP, Dept Pharmacol, Ribeirao Preto, Brazil
机构:
Univ Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USAUniv Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USA
Hayashi, Kazuhiro
Lesnak, Joseph B. B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USAUniv Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USA
Lesnak, Joseph B. B.
Plumb, Ashley N. N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USAUniv Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USA
Plumb, Ashley N. N.
Rasmussen, Lynn A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USAUniv Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USA
Rasmussen, Lynn A. A.
Sluka, Kathleen A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USAUniv Iowa, Dept Phys Therapy & Rehabil Sci, 1-248 Med Educ Bldg, Iowa City, IA 52242 USA
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
He, Yuan
Hara, Hideki
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Hara, Hideki
Nunez, Gabriel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
He, Yuan
Zeng, Melody Y.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Zeng, Melody Y.
Yang, Dahai
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R ChinaUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Yang, Dahai
Metro, Benny
论文数: 0引用数: 0
h-index: 0
机构:
Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, IsraelUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Metro, Benny
Nunez, Gabriel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
机构:
Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USAUniv Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USA
Hoffman, HM
Mueller, JL
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USA
Mueller, JL
Broide, DH
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USA
Broide, DH
Wanderer, AA
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USA
Wanderer, AA
Kolodner, RD
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, San Diego, CA 92103 USA