Association between vmPFC gray matter volume and smoking initiation in adolescents

被引：8

作者：

Xiang, Shitong ^{[1
,2
]}

Jia, Tianye ^{[1
,2
,3
,4
]}

Xie, Chao ^{[1
,2
]}

Cheng, Wei ^{[1
,2
]}

Chaarani, Bader ^{[5
,6
]}

Banaschewski, Tobias J. ^{[7
]}

Barker, Gareth ^{[8
]}

Bokde, Arun L. W. ^{[9
,10
]}

Buechel, Christian ^{[11
]}

Desrivieres, Sylvane ^{[4
]}

Flor, Herta ^{[12
,13
]}

Grigis, Antoine A. ^{[14
]}

Gowland, Penny ^{[15
]}

Bruehl, Ruediger ^{[16
]}

Martinot, Jean-Luc ^{[17
]}

Martinot, Marie-Laure Paillere ^{[17
,18
]}

Nees, Frauke ^{[7
,12
,19
]}

Orfanos, Dimitri Papadopoulos ^{[13
]}

Poustka, Luise ^{[20
]}

Hohmann, Sarah H. ^{[7
]}

Froehner, Juliane N. ^{[21
]}

Smolka, Michael ^{[21
]}

Vaidya, Nilakshi ^{[22
,23
,24
,25
]}

Walter, Henrik ^{[22
,23
,24
,25
]}

Whelan, Robert ^{[26
]}

Garavan, Hugh ^{[5
,6
]}

Schumann, Gunter J. ^{[1
,3
,22
,23
,24
,25
,27
]}

Sahakian, Barbara W. ^{[1
,28
,29
]}

Robbins, Trevor ^{[1
,29
,30
]}

Feng, Jianfeng ^{[1
,2
,31
,32
]}

IMAGEN Consortium

机构：

[1] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence IST, Shanghai, Peoples R China

[2] Fudan Univ, Key Lab Computat Neurosci & Brain Inspired Intelli, Minist Educ, Shanghai, Peoples R China

[3] Fudan Univ, Ctr Populat Neurosci & Stratified Med, PONS Ctr, ISTBI, Shanghai, Peoples R China

[4] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England

[5] Univ Vermont, Dept Psychiat, Burlington, VT USA

[6] Univ Vermont, Dept Psychol, Burlington, VT USA

[7] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Child & Adolescent Psychiat & Psychotherapy, Mannheim, Germany

[8] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London, England

[9] Trinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland

[10] Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin, Ireland

[11] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany

[12] Heidelberg Univ, Inst Cognit & Clin Neurosci, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany

[13] Univ Mannheim, Sch Social Sci, Dept Psychol, Mannheim, Germany

[14] Univ Paris Saclay, NeuroSpin, CEA, Gif Sur Yvette, France

[15] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Nottingham, England

[16] Phys Tech Bundesanstalt PTB, Berlin, Germany

[17] Univ Paris Saclay, Ecole Normale Super Paris Saclay, Inst Natl Sante & Rech Med, CNRS UMR9010,Ctr Borelli,INSERM U1299 Trajectoires, Gif Sur Yvette, France

[18] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Child & Adolescent Psychiat, Paris, France

[19] Univ Kiel, Univ Med Ctr Schleswig Holstein, Inst Med Psychol & Med Sociol, Kiel, Germany

[20] Univ Hosp Heidelberg, Ctr Psychosocial Med, Dept Child & Adolescent Psychiat, Heidelberg, Germany

[21] Tech Univ Dresden, Dept Psychiat & Psychotherapy, Dresden, Germany

[22] Charite Univ Med Berlin, Dept Psychiat & Neurosci, Berlin, Germany

[23] Free Univ Berlin, Berlin, Germany

[24] Humboldt Univ, Berlin, Germany

[25] Berlin Inst Hlth, Berlin, Germany

[26] Trinity Coll Dublin, Global Brain Hlth Inst, Sch Psychol, Dublin, Ireland

[27] Charite Univ Med Berlin, Ctr Populat Neurosci & Stratified Med, PONS Ctr, Berlin, Germany

[28] Univ Cambridge, Dept Psychiat, Cambridge, England

[29] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge, England

[30] Univ Cambridge, Dept Psychol, Cambridge, England

[31] Univ Warwick, Dept Comp Sci, Coventry, England

[32] Zhangjiang Fudan Int Innovat Ctr, Shanghai, Peoples R China

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会; 中国国家自然科学基金;

关键词：

RESPONSE-INHIBITION; CIGARETTE-SMOKING; DRUG-ADDICTION; BRAIN-FUNCTION; REINFORCEMENT; MECHANISMS; NICOTINE; SEEKING; RISK; NEUROCIRCUITRY;

D O I：

10.1038/s41467-023-40079-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFCGMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.

引用

页数：13

共 68 条

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