Microvascular dysfunction in women with a history of hypertensive disorders of pregnancy: A population-based retrospective cohort study

被引:2
作者
Bjoerkman, Stina [1 ,11 ]
Lilliecreutz, Caroline [2 ,3 ]
Bladh, Marie [2 ,3 ]
Stromberg, Tomas [4 ]
Ostgren, Carl Johan [5 ,6 ]
Mahmoud, Arina [7 ]
Kafashian, Arian [7 ]
Bergstrand, Sara [8 ]
Lawesson, Sofia Sederholm [9 ,10 ]
机构
[1] Linkoping Univ, Dept Obstet & Gynaecol Norrkoping, Dept Biomed & Clin Sci, Linkoping, Sweden
[2] Linkoping Univ, Dept Obstet & Gynaecol Linkoping, Linkoping, Sweden
[3] Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden
[4] Linkoping Univ, Dept Biomed Engn, Linkoping, Sweden
[5] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden
[6] Linkoping Univ, CMIV Ctr Med Image Sci & Visualizat, Linkoping, Sweden
[7] Linkoping Univ, Linkoping, Sweden
[8] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden
[9] Linkoping Univ, Dept Cardiol, Linkoping, Sweden
[10] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden
[11] Linkoping Univ, Dept Obstet & Gynaecol Norrkoping, Dept Biomed & Clin Sci, SE-58185 Linkoping, Sweden
关键词
cardiovascular disease; endothelial dysfunction; hypertension pregnancy-induced; microcirculation; pre-eclampsia; pregnancy; FLOW-MEDIATED DILATION; ENDOTHELIAL FUNCTION; PREECLAMPSIA-PATHOPHYSIOLOGY; RISK; DISEASE; COMMON;
D O I
10.1111/1471-0528.17665
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
ObjectiveTo evaluate microvascular function in women with previous hypertensive disorders of pregnancy (HDP).DesignRetrospective population-based cohort study.SettingLinkoping, Sweden.PopulationWomen aged 50-65 years, participating in the Swedish CArdioPulmonary bioImage Study (SCAPIS) at one site (Linkoping) 2016-18, who underwent microcirculatory assessment (N = 1222).MethodsForearm skin comprehensive microcirculatory assessment was performed with a PeriFlux PF6000 EPOS (Enhanced Perfusion and Oxygen Saturation) system measuring oxygen saturation and total speed resolved perfusion. Obstetric records were reviewed to identify women with previous HDP. Data on cardiovascular risk factors, comorbidities, medication, lifestyle, anthropometric data, and biochemical analyses were obtained from SCAPIS. The microcirculatory data were compared between women with and without previous HDP.Main outcome measuresSkin microcirculatory oxygen saturation and total speed resolved perfusion at baseline and post-ischaemic peak.ResultsWomen with previous pre-eclampsia displayed impaired post-ischaemic peak oxygen saturation compared with women with normotensive pregnancies (88%, interquartile range [IQR] 84-89% vs 91%, IQR 87-94%, p = 0.001) 6-30 years after pregnancy. The difference remained after multivariable adjustment (& beta; -2.69, 95% CI -4.93 to -0.45).ConclusionsThe findings reveal microvascular dysfunction at long-term follow up in women with previous pre-eclampsia and strengthen the possible role of endothelial dysfunction as a link to the increased risk of cardiovascular disease in women with HDP.
引用
收藏
页码:433 / 443
页数:11
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共 38 条
  • [31] Preeclampsia Pathophysiology, Challenges, and Perspectives
    Rana, Sarosh
    Lemoine, Elizabeth
    Granger, Joey
    Karumanchi, S. Ananth
    [J]. CIRCULATION RESEARCH, 2019, 124 (07) : 1094 - 1112
  • [32] Hypertension in Pregnancy and Later Cardiovascular Risk Common Antecedents?
    Romundstad, Pal R.
    Magnussen, Elisabeth B.
    Smith, George Davey
    Vatten, Lars J.
    [J]. CIRCULATION, 2010, 122 (06) : 579 - 584
  • [33] Insulin resistance relates to microvascular reactivity 23 years after preeclampsia
    Spaan, Julia J.
    Houben, Alphons J. H. M.
    Musella, Angela
    Ekhart, Timo
    Spaanderman, Marc E. A.
    Peeters, Louis L. H.
    [J]. MICROVASCULAR RESEARCH, 2010, 80 (03) : 417 - 421
  • [34] Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy
    Stuart, Jennifer J.
    Tanz, Lauren J.
    Rimm, Eric B.
    Spiegelman, Donna
    Missmer, Stacey A.
    Mukamal, Kenneth J.
    Rexrode, Kathryn M.
    Rich-Edwards, Janet W.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2022, 79 (19) : 1901 - 1913
  • [35] Endothelial and kidney function in women with a history of preeclampsia and healthy parous controls: A case control study
    van Balen, Veronica A. Lopes
    Spaan, Julia J.
    Cornelis, Tom
    Heidema, Wieteke M.
    Scholten, Ralph R.
    Spaanderman, Marc E. A.
    [J]. MICROVASCULAR RESEARCH, 2018, 116 : 71 - 76
  • [36] Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia A Systematic Review and Meta-Analysis
    Weissgerber, Tracey L.
    Milic, Natasa M.
    Milin-Lazovic, Jelena S.
    Garovic, Vesna D.
    [J]. HYPERTENSION, 2016, 67 (02) : 415 - 423
  • [37] Preeclampsia and Future Cardiovascular Health A Systematic Review and Meta-Analysis
    Wu, Pensee
    Haththotuwa, Randula
    Kwok, Chun Shing
    Babu, Aswin
    Kotronias, Rafail A.
    Rushton, Claire
    Zaman, Azfar
    Fryer, Anthony A.
    Kadam, Umesh
    Chew-Graham, Carolyn A.
    Mamas, Mamas A.
    [J]. CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 2017, 10 (02):
  • [38] Parity and Risk of Cardiovascular Disease in Women over 45 Years in the United States: National Health and Nutrition Examination Survey 2007-2018
    Xing, Zailing
    Alman, Amy C.
    Kirby, Russell S.
    [J]. JOURNAL OF WOMENS HEALTH, 2022, 31 (10) : 1459 - 1466