Radiation damage to biological macromolecules

被引：19
|
作者：
Garman, Elspeth F. [1 ]
Weik, Martin [2 ]
机构：
[1] Dorothy Crowfoot Hodgkin Bldg, Dept Biochem, South Pk Rd, Oxford OX1 3QU, England
[2] Univ Grenoble Alpes, Inst Biol Structurale, CNRS, CEA, F-38044 Grenoble, France
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2023年 / 82卷
关键词：
Radiation damage; Reduction; X-ray free electron lasers; X-rays; Dose; Global damage; Specific structural damage; Disulphide bond breakage; Synchrotrons; Electrons; Microscopy; X-RAY; ROOM-TEMPERATURE; DATA-COLLECTION; SERIAL SYNCHROTRON; PROTEIN CRYSTALLOGRAPHY; CATALYTIC PATHWAY; ACTIVE-SITE; CRYO-EM; CRYSTALS; RESOLUTION;
D O I：
10.1016/j.sbi.2023.102662
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, we describe recent research developments into radiation damage effects in macromolecular X-ray crystallog-raphy observed at synchrotrons and X-ray free electron lasers. Radiation damage in small molecule X-ray crystallography, small angle X-ray scattering experiments, microelectron diffraction, and single particle cryo-electron microscopy is briefly covered.
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收藏
页数：11
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