Simultaneous determination of fourteen pharmaceuticals in sewage sludge using online solid-phase extraction-liquid chromatography-tandem mass spectrometry combined with accelerated solvent extraction

被引：5

作者：

Sun, Shaojing ^{[1
]}

Meng, Fan ^{[2
,3
]}

Qi, Hong ^{[2
,3
]}

机构：

[1] Hebei Univ Engn, Coll Energy & Environm Engn, Hebei Key Lab Air Pollut Cause & Impact, Handan 056038, Peoples R China

[2] Harbin Inst Technol, Key Lab Urban Water Resource & Environm, Harbin, Peoples R China

[3] Harbin Inst Technol, Sch Environm, Harbin 150090, Peoples R China

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2023年 / 30卷 / 22期

基金：

美国国家科学基金会;

关键词：

ASE; Online SPE; HPLC-MS/MS; Pharmaceuticals; Sludge; ASSISTED EXTRACTION; ANTIBIOTICS; ANTIMICROBIALS; CONTAMINANTS; REMOVAL; WWTPS; RISK; LOAD; SPE;

D O I：

10.1007/s11356-023-26072-8

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

An online solid-phase extraction (SPE) liquid chromatography tandem mass spectrometry method (HPLC-MS/MS) combined with accelerated solvent extraction (ASE) was developed for simultaneous determination of 14 pharmaceuticals in sludge. In the online SPE procedures, ultrapure water with no additives was used as the loading solvent. In addition, low molecular weight targets such as atenolol were difficult to retain on SPE column after acetone was added to the washing solvent. The response signal of analytes can be greatly improved by adding 0.2% formic acid to the mobile phase. Under the optimized conditions, the recoveries of all the analytes ranged between 75.1 and 112%. Moreover, the limit of detections ranged from 1.8 to 7.9 ug/kg. The precision of analytical data was determined with relative standard deviation (RSD)<= 4.87%. This method was successfully applied to determine the concentration of pharmaceuticals in sludge.

引用

页码：62522 / 62531

页数：10

共 56 条

[1] A review of the modern principles and applications of solid-phase extraction techniques in chromatographic analysis [J].