Lurasidone in first-episode psychosis with predominant depressive symptoms: a case report

被引：4
作者：
Ricci, Valerio [1 ,3 ]
Di Salvo, Gabriele [2 ]
Maina, Giuseppe [2 ]
机构：
[1] San Luigi Gonzaga Univ Hosp, Dept Psychiat, Orbassano, Regione Gonzole, Italy
[2] Univ Turin, Rita Levi Montalcini Dept Neurosci, Turin, Italy
[3] San Luigi Gonzaga Univ Hosp, Dept Psychiat, Reg Gonzole 10, I-10043 Turin, Italy
来源：
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 2023年 / 38卷 / 04期
关键词：
depression; first-episode psychosis; lurasidone; negative symptoms; psychotic symptoms; schizophrenia; SCHIZOPHRENIA; 5-HT7;
D O I：
10.1097/YIC.0000000000000465
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Lurasidone is an atypical antipsychotic approved for the treatment of schizophrenia and bipolar depression. It seems to have an antidepressant effect due to 5-HT7 as well as 5-HT2A and 5-HT1a receptor affinity. Here we present a case of a 19-year-old male patient with first-episode psychosis (FEP) and predominant depressive symptoms. Remarkable clinical and functional improvement was observed 3 months after the beginning of lurasidone treatment. The patient's depressive symptoms disappear with a dramatic reduction of psychotic ones, with good tolerance of the drug and without adverse effects. Lurasidone seems to be a promising treatment option for FEP with predominant depressive symptoms.
引用
收藏
页码：275 / 280
页数：6
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