N6-methyladenosine in macrophage function: a novel target for metabolic diseases

被引：28

作者：

Zhu, Xiao ^{[1
,2
]}

Tang, HaoJun ^{[1
]}

Yang, Min ^{[1
]}

Yin, Kai ^{[1
,2
,3
]}

机构：

[1] Guilin Med Univ, Guangxi Key Lab Diabet Syst Med, Guilin 541100, Guangxi, Peoples R China

[2] Guilin Med Univ, Affiliated Hosp 2, Dept Cardiol, Guilin 541199, Guangxi, Peoples R China

[3] Guilin Med Univ, Affiliated Hosp 2, Guangxi Hlth Commiss Key Lab Glucose & Lipid Metab, Guilin 541199, Guangxi, Peoples R China

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2023年 / 34卷 / 02期

关键词：

MESSENGER-RNA; M(6)A; METTL3; DIFFERENTIATION; METHYLATION; DEMETHYLASE; CELLS; STEM; ATHEROSCLEROSIS; PROLIFERATION;

D O I：

10.1016/j.tem.2022.12.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

N6-methyladenosine (m6A) is one of the most prevalent internal transcriptional modifications. Evidence has highlighted changes in m6A in metabolic disorders and various metabolic diseases. However, the precise mechanisms of these m6A changes in such conditions are not understood. Macrophages are crucial for the innate immune system and exert either beneficial or harmful roles in met-abolic disease. Notably, m6A was found to be closely related to macrophage phenotype and dysfunction. In this review, we summarize m6A in macrophage function from the perspective of macrophage development, activation, and po-larization, pyroptosis, and metabolic disorders. Furthermore, we discuss how m6A-mediated macrophage function affects metabolic diseases, including ath-erosclerosis and nonalcoholic fatty liver disease (NAFLD). Finally, we discuss challenges and prospects for m6A in macrophage and metabolic diseases with the aim of providing guidance for the treatment of metabolic diseases.

引用

页码：66 / 84

页数：19

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