Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature

被引：5

作者：

Murray, Jason ^{[1
]}

Lu, Zhen A. ^{[1
]}

Miller, Karin ^{[2
]}

Meadows, Alex ^{[1
]}

Totten, Marissa ^{[1
]}

Zhang, Sean X. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Pathol, Sch Med, Baltimore, MD 21287 USA

[2] Childrens Hosp Los Angeles, Dept Pathol, Los Angeles, CA 90027 USA

来源：

JOURNAL OF FUNGI | 2023年 / 9卷 / 03期

关键词：

aspergillosis; mucormycosis; coinfection; autopsy; histology; REGION;

D O I：

10.3390/jof9030357

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Coinfection with invasive aspergillosis and mucormycosis in immunocompromised patients has been reported but is rarely confirmed by tissue histology or autopsy. Serum fungal biomarkers and culture are the primary diagnostic tools but are suboptimal for detecting fungal coinfection. Here, we present the cases of two patients who were immunocompromised due to hematologic malignancy where disseminated aspergillosis and mucormycosis coinfection was only diagnosed upon autopsy despite extensive fungal diagnostic workup, and also review recent literature of such instances of coinfection.

引用

页数：8

共 15 条

[1] A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil [J].

Dantas, Katia Cristina ;

Mauad, Thais ;

Saldiva de Andre, Carmen D. ;

Bierrenbach, Ana Luiza ;

Nascimento Saldiva, Paulo Hilario .

SCIENTIFIC REPORTS, 2021, 11 (01)

[2] Diagnosis of Fungal Infections A Systematic Review and Meta-Analysis Supporting American Thoracic Society Practice Guideline [J].

Haydour, Qusay ;

Hage, Chadi A. ;

Carmona, Eva M. ;

Epelbaum, Oleg ;

Evans, Scott E. ;

Gabe, Luke M. ;

Knox, Kenneth S. ;

Kolls, Jay K. ;

Wengenack, Nancy L. ;

Prokop, Larry J. ;

Limper, Andrew H. ;

Murad, M. Hassan .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2019, 16 (09) :1179-1188

[3] An autopsy case of pulmonary fissure induced by zygomycosis [J].

Imai, Yuichiro ;

Adachi, Yasushi ;

Kimura, Takashi ;

Nakano, Chikara ;

Shimizu, Toshiki ;

Shi, Ming ;

Okigaki, Mitsuhiko ;

Shimo, Tomohiko ;

Kaneko, Kazunari ;

Ikehara, Susumu .

INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2013, 6 :575-579

[4] Lipoid pneumonia with chronic myelomonocytic leukemia [J].

Itoh, Yasushi ;

Segawa, Hidekazu ;

Kito, Katsuyuki ;

Hodohara, Keiko ;

Ishigaki, Hirohito ;

Sugihara, Hiroyuki ;

Fujiyama, Yoshihide ;

Ogasawara, Kazumasa .

PATHOLOGY RESEARCH AND PRACTICE, 2009, 205 (02) :143-147

[5]

Kim JH, 2022, ACUTE CRIT CARE, DOI DOI 10.4266/ACC.2021.01340

[6] Evaluation of Nucleic Acid Sequencing of the D1/D2 Region of the Large Subunit of the 28S rDNA and the Internal Transcribed Spacer Region Using SmartGene IDN Software for Identification of Filamentous Fungi in a Clinical Laboratory [J].

Kwiatkowski, Nicole P. ;

Babiker, Wisal M. ;

Merz, William G. ;

Carroll, Karen C. ;

Zhang, Sean X. .

JOURNAL OF MOLECULAR DIAGNOSTICS, 2012, 14 (04) :393-401

[7]

Low Chian-Yong, 2011, F1000 Med Rep, V3, P14, DOI 10.3410/M3-14

[8] Combined mucormycosis and aspergillosis of the oro-sinonasal region in a patient affected by Castleman disease [J].

Maiorano, E ;

Favia, G ;

Capodiferro, S ;

Montagna, M ;

Lo Muzio, L .

VIRCHOWS ARCHIV, 2005, 446 (01) :28-33

[9] Concomitant cerebral aspergillosis and mucormycosis in an immunocompetent woman treated with corticosteroids [J].

Mantero, Vittorio ;

Basilico, Paola ;

Pozzetti, Ugo ;

Tonolo, Silvia ;

Rossi, Giorgio ;

Spena, Giannantonio ;

Rigamonti, Andrea ;

Salmaggi, Andrea .

JOURNAL OF NEUROVIROLOGY, 2020, 26 (02) :277-280

[10]

Ravindra Chari M, 2021, Sultan Qaboos Univ Med J, V21, P495, DOI 10.18295/squmj.8.2021.126

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