How does exosome cause diabetes?

被引：1

作者：

Hu, Fei ^{[1
]}

Yu, Yicong ^{[2
]}

Xu, Hongming ^{[3
]}

机构：

[1] Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo, Peoples R China

[2] Zhejiang Ctr Anim Dis Control, Hangzhou, Peoples R China

[3] Wenzhou Med Univ, Affiliated Cixi Hosp, Dept Orthopaed Surg, 999 South Second Ring Rd, Ningbo 315300, Zhejiang, Peoples R China

来源：

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2024年 / 23卷 / 03期

关键词：

Exosome; Diabetes; Insulin resistance; beta-cells; INSULINOMA-RELEASED EXOSOMES; EXTRACELLULAR VESICLES; ADIPOSE-TISSUE; CELL FUNCTION; OBESITY; INFLAMMATION; ADIPOCYTES; BIOMARKERS; SECRETION; RESPONSES;

D O I：

10.1007/s42000-024-00525-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Exosomes are extracellular vesicles that are widely distributed in multiple cell types and circulating body fluids. They have a specific effect on the target cells by releasing different vesicle contents. They have recently been recognized as important means of intercellular communication, being involved, for example, in the development of diabetes by increasing beta-cell apoptosis, activating autoimmunity, and regulating cytokines to affect islet beta-cell function and insulin sensitivity. An in-depth study of the role of exosome in the pathogenesis of diabetes may therefore provide a novel means of diagnosing and treating diabetes. In this review, we detail how exosome is involved in the development of diabetes.

引用

页码：385 / 393

页数：9

共 60 条

[1] Extracellular vesicles in metabolic disease [J].

Akbar, Naveed ;

Azzimato, Valerio ;

Choudhury, Robin P. ;

Aouadi, Myriam .

DIABETOLOGIA, 2019, 62 (12) :2179-2187

[2] Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease [J].

Anel, Alberto ;

Gallego-Lleyda, Ana ;

de Miguel, Diego ;

Naval, Javier ;

Martinez-Lostao, Luis .

CELLS, 2019, 8 (02)

[3] Insulinoma-released exosomes activate autoreactive marginal zone-like B cells that expand endogenously in prediabetic NOD mice [J].

Bashratyan, Roman ;

Sheng, Huiming ;

Regn, Danielle ;

Rahman, M. Jubayer ;

Dai, Yang D. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2013, 43 (10) :2588-2597

[4] Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses [J].

Bobrie, Angelique ;

Colombo, Marina ;

Raposo, Graca ;

Thery, Clotilde .

TRAFFIC, 2011, 12 (12) :1659-1668

[5] Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway [J].

Cai, Zhijian ;

Yang, Fei ;

Yu, Lei ;

Yu, Zhou ;

Jiang, Lingling ;

Wang, Qingqing ;

Yang, Yunshan ;

Wang, Lie ;

Cao, Xuetao ;

Wang, Jianli .

JOURNAL OF IMMUNOLOGY, 2012, 188 (12) :5954-5961

[6] Emerging role of neuronal exosomes in the central nervous system [J].

Chivet, Mathilde ;

Hemming, Fiona ;

Pernet-Gallay, Karin ;

Fraboulet, Sandrine ;

Sadoul, Remy .

FRONTIERS IN PHYSIOLOGY, 2012, 3

[7] Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity [J].

Cianciaruso, Chiara ;

Phelps, Edward A. ;

Pasquier, Miriella ;

Hamelin, Romain ;

Demurtas, Davide ;

Ahmed, Mohamed Alibashe ;

Piemonti, Lorenzo ;

Hirosue, Sachiko ;

Swartz, Melody A. ;

De Palma, Michele ;

Hubbell, Jeffrey A. ;

Baekkeskov, Steinunn .

DIABETES, 2017, 66 (02) :460-473

[8] Genetics of diabetes mellitus and diabetes complications [J].

Cole, Joanne B. ;

Florez, Jose C. .

NATURE REVIEWS NEPHROLOGY, 2020, 16 (07) :377-390

[9] Immunometabolism of human autoimmune diseases: from metabolites to extracellular vesicles [J].

de Candia, Paola ;

De Rosa, Veronica ;

Gigantino, Vincenzo ;

Botti, Gerardo ;

Ceriello, Antonio ;

Matarese, Giuseppe .

FEBS LETTERS, 2017, 591 (19) :3119-3134

[10] Urinary Exosomal miRNA Signature in Type II Diabetic Nephropathy Patients [J].

Delic, Denis ;

Eisele, Claudia ;

Schmid, Ramona ;

Baum, Patrick ;

Wiech, Franziska ;

Gerl, Martin ;

Zimdahl, Heike ;

Pullen, Steven S. ;

Urquhart, Richard .

PLOS ONE, 2016, 11 (03)

← 1 2 3 4 5 6 →