The impact of prior SARS-CoV-2 infection on host inflammatory cytokine profiles in patients with TB or other respiratory diseases

被引:2
作者
Cottam, Annabelle [1 ]
Manneh, Ismaila L. [2 ]
Gindeh, Awa [2 ]
Sillah, Abdou K. [2 ]
Cham, Ousainou [2 ]
Mendy, Joseph [2 ]
Barry, Amadou [2 ]
Coker, Edward G. [2 ]
Daffeh, Georgetta K. [2 ]
Badjie, Simon [2 ]
Barry, Salieu [2 ]
Owolabi, Olumuyiwa [2 ]
Winter, Jill [3 ]
Walzl, Gerhard [4 ]
Sutherland, Jayne S. [2 ]
机构
[1] Fac Infect & Trop Dis, London Sch Hyg & Trop Med, London, England
[2] Gambia London Sch Hyg & Trop Med, Med Res Council Unit, Vaccines & Immun Theme, Fajara, Gambia
[3] Catalysis Fdn Hlth, Emeryville, CA USA
[4] Stellenbosch Univ, Div Mol Biol & Human Genet, Tygerberg, South Africa
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金
比尔及梅琳达.盖茨基金会;
关键词
tuberculosis; COVID-19; inflammatory profiles; respiratory disease; cytokines; TUBERCULOSIS; RESPONSES;
D O I
10.3389/fimmu.2023.1292486
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Tuberculosis (TB) and COVID-19 are the two leading causes of infectious disease mortality worldwide, and their overlap is likely frequent and inevitable. Previous research has shown increased mortality in TB/COVID-coinfected individuals, and emerging evidence suggests that COVID-19 may increase susceptibility to TB. However, the immunological mechanisms underlying these interactions remain unclear. In this study, we aimed to elucidate the impact of prior or concurrent COVID-19 infection on immune profiles of TB patients and those with other respiratory diseases (ORD).Methods: Serum and nasopharyngeal samples were collected from 161 Gambian adolescents and adults with either TB or an ORD. Concurrent COVID-19 infection was determined by PCR, while prior COVID-19 was defined by antibody seropositivity. Multiplex cytokine immunoassays were used to quantify 27 cytokines and chemokines in patient serum samples at baseline, and throughout treatment in TB patients.Results: Strikingly, TB and ORD patients with prior COVID-19 infection were found to have significantly reduced expression of several cytokines, including IL-1 beta, TNF-alpha and IL-7, compared to those without (p<0.035). Moreover, at month-six of anti-TB treatment, seropositive patients had lower serum Basic FGF (p=0.0115), IL-1 beta (p=0.0326) and IL-8 (p=0.0021) than seronegative. TB patients with acute COVID-19 coinfection had lower levels of IL-8, IL-13, TNF-alpha and IP-10 than TB-only patients, though these trends did not reach significance (p>0.035).Conclusions: Our findings demonstrate that COVID-19 infection alters the subsequent response to TB and ORDs, potentially contributing to pathogenesis. Further work is necessary to determine whether COVID-19 infection accelerates TB disease progression, though our results experimentally support this hypothesis.
引用
收藏
页数:10
相关论文
共 35 条
  • [1] Activation of tuberculosis in recovered COVID-19 patients: a case report
    Al-kayali, Rawaa S.
    Kashkash, Mohamad F.
    Alhajji, Azzam Alhussein H.
    Khouri, Abdullah
    [J]. ANNALS OF MEDICINE AND SURGERY, 2023, 85 (02): : 280 - 283
  • [2] STINGing type I IFN-mediated immunopathology in COVID-19
    Andreakos, Evangelos
    [J]. NATURE IMMUNOLOGY, 2022, 23 (04) : 478 - 480
  • [3] [Anonymous], 2022, Global tuberculosis report 2022
  • [4] Waning of IgG, Total and Neutralizing Antibodies 6 Months Post-Vaccination with BNT162b2 in Healthcare Workers
    Bayart, Jean-Louis
    Douxfils, Jonathan
    Gillot, Constant
    David, Clara
    Mullier, Francois
    Elsen, Marc
    Eucher, Christine
    Van Eeckhoudt, Sandrine
    Roy, Tatiana
    Gerin, Vincent
    Wieers, Gregoire
    Laurent, Christine
    Closset, Melanie
    Dogne, Jean-Michel
    Favresse, Julien
    [J]. VACCINES, 2021, 9 (10)
  • [5] An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    Berry, Matthew P. R.
    Graham, Christine M.
    McNab, Finlay W.
    Xu, Zhaohui
    Bloch, Susannah A. A.
    Oni, Tolu
    Wilkinson, Katalin A.
    Banchereau, Romain
    Skinner, Jason
    Wilkinson, Robert J.
    Quinn, Charles
    Blankenship, Derek
    Dhawan, Ranju
    Cush, John J.
    Mejias, Asuncion
    Ramilo, Octavio
    Kon, Onn M.
    Pascual, Virginia
    Banchereau, Jacques
    Chaussabel, Damien
    O'Garra, Anne
    [J]. NATURE, 2010, 466 (7309) : 973 - U98
  • [6] Cascella M., 2023, StatPearls
  • [7] Tuberculosis and COVID-19 co-infection: description of the global cohort
    Casco, Nicolas
    Jorge, Alberto Levi
    Palmero, Domingo Juan
    Alffenaar, Jan-Willem
    Denholm, Justin
    Fox, Greg J.
    Ezz, Wafaa
    Cho, Jin-Gun
    Skrahina, Alena
    Solodovnikova, Varvara
    Bachez, Pierre
    Piubello, Alberto
    Arbex, Marcos Abdo
    Alves, Tatiana
    Rabahi, Marcelo Fouad
    Pereira, Giovana Rodrigues
    Sales, Roberta
    Silva, Denise Rossato
    Saffie, Muntasir M.
    Miranda, Ruth Caamano
    Cancino, Viviana
    Carbonell, Monica
    Cisterna, Catalina
    Concha, Clorinda
    Cruz, Arturo
    Salinas, Nadia Escobar
    Revillot, Macarena Espinoza
    Valdes, Joaquin Farias
    Fernandez, Israel
    Flores, Ximena
    Tapia, Patricia Gallegos
    Garavagno, Ana
    Vera, Carolina Guajardo
    Bahamondes, Martina Hartwig
    Merino, Luis Moyano
    Munoz, Eduardo
    Munoz, Camila
    Navarro, Indira
    Subiabre, Jorge Navarro
    Ortega, Carlos
    Palma, Sofia
    Pradenas, Ana Maria
    Pereira, Gloria
    Castillo, Patricia Perez
    Pinto, Monica
    Pizarro, Rolando
    Bidegain, Francisco Rivas
    Rodriguez, Patricia
    Sanchez, Cristina
    Salinas, Angeles Serrano
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2022, 59 (03)
  • [8] The potential impact of the COVID-19 pandemic on the tuberculosis epidemic a modelling analysis
    Cilloni, Lucia
    Fu, Han
    Vesga, Juan F.
    Dowdy, David
    Pretorius, Carel
    Ahmedov, Sevim
    Nair, Sreenivas A.
    Mosneaga, Andrei
    Masini, Enos
    Sahu, Suvanand
    Arinaminpathy, Nimalan
    [J]. ECLINICALMEDICINE, 2020, 28
  • [9] Mycobacteria-specific cytokine responses as correlates of treatment response in active and latent tuberculosis
    Clifford, Vanessa
    Tebruegge, Marc
    Zufferey, Christel
    Germano, Susie
    Forbes, Ben
    Cosentino, Lucy
    McBryde, Emma
    Eisen, Damon
    Robins-Browne, Roy
    Street, Alan
    Denholm, Justin
    Curtis, Nigel
    [J]. JOURNAL OF INFECTION, 2017, 75 (02) : 132 - 145
  • [10] Innate immunity: the first line of defense against SARS-CoV-2
    Diamond, Michael S.
    Kanneganti, Thirumala-Devi
    [J]. NATURE IMMUNOLOGY, 2022, 23 (02) : 165 - 176