Atypical Presentation of Liver Metastases of Prostate Cancer in 68Ga-PSMA-11 PET/CT

被引：1
作者：
Stanzel, Susanne [1 ,2 ]
Weitzer, Friedrich [1 ]
Janek, Elmar
Plhak, Elisabeth [1 ]
Aigner, Reingard M. [1 ]
机构：
[1] Med Univ Graz, Dept Radiol, Graz, Austria
[2] Med Univ Graz, De Dept Radiol, Div Nucl Med, Auenbruggerpl 9A, A-8036 Graz, Austria
来源：
CLINICAL NUCLEAR MEDICINE | 2023年 / 48卷 / 12期
关键词：
Ga-68-PSMA-11; PET/CT; metastatic castration-resistant prostate cancer; PSMA-negative liver metastases;
D O I：
10.1097/RLU.0000000000004898
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Ga-68-PSMA-11 (Ga-68-prostate-specific membrane antigen-11) PET/CT continues to have a great clinical value for staging in prostate cancer. Lymph nodes and bone are the most typical metastatic sites of prostate cancer, whereas liver metastases are rare and usually show focally increased tracer uptake in Ga-68-PSMA-11 PET/CT. Here, we present an 88-year-old man with histologically proven metastatic castration-resistant prostate cancer and extensive PSMA-negative liver metastases identified by(68)Ga-PSMA-11 PET/CT. This finding is remarkable because the decreased liver uptake of Ga-68-PSMA-11 may resemble a primary hepatic tumor.
引用
收藏
页码：1064 / 1065
页数：2
相关论文
共 13 条
[1]   Metastatic patterns of prostate cancer:: An autopsy study of 1,589 patients [J].
Bubendorf, L ;
Schöpfer, A ;
Wagner, U ;
Sauter, G ;
Moch, H ;
Willi, N ;
Gasser, TC ;
Mihatsch, MJ .
HUMAN PATHOLOGY, 2000, 31 (05) :578-583
[2]  
Bunck AC, 2017, CASE REP ONCOL, V10, P627, DOI 10.1159/000478004
[3]   68Ga-PSMA-PET/CT for the evaluation of liver metastases in patients with prostate cancer [J].
Damjanovic, Jonathan ;
Janssen, Jan-Carlo ;
Prasad, Vikas ;
Diederichs, Gerd ;
Walter, Thula ;
Brenner, Winfried ;
Makowski, Marcus R. .
CANCER IMAGING, 2019, 19 (1)
[4]   Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy [J].
Denmeade, Samuel R. ;
Mhaka, Annastasiah M. ;
Rosen, D. Marc ;
Brennen, W. Nathaniel ;
Dalrymple, Susan ;
Dach, Ingrid ;
Olesen, Claus ;
Gurel, Bora ;
DeMarzo, Angelo M. ;
Wilding, George ;
Carducci, Michael A. ;
Dionne, Craig A. ;
Moller, Jesper V. ;
Nissen, Poul ;
Christensen, S. Brogger ;
Isaacs, John T. .
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (140)
[5]   Distribution of Metastatic Sites in Patients With Prostate Cancer: A Population-Based Analysis [J].
Gandaglia, Giorgio ;
Abdollah, Firas ;
Schiffmann, Jonas ;
Trudeau, Vincent ;
Shariat, Shahrokh F. ;
Kim, Simon P. ;
Perrotte, Paul ;
Montorsi, Francesco ;
Briganti, Alberto ;
Quoc-Dien Trinh ;
Karakiewicz, Pierre I. ;
Sun, Maxine .
PROSTATE, 2014, 74 (02) :210-216
[6]  
Kelly WK., 2012, J Clin Oncol, V30
[7]   EANM procedure guidelines for radionuclide therapy with 177Lu-labelled PSMA-ligands (177Lu-PSMA-RLT) [J].
Kratochwil, Clemens ;
Fendler, Wolfgang Peter ;
Eiber, Matthias ;
Baum, Richard ;
Bozkurt, Murat Fani ;
Czernin, Johannes ;
Delgado Bolton, Roberto C. ;
Ezziddin, Samer ;
Forrer, Flavio ;
Hicks, Rodney J. ;
Hope, Thomas A. ;
Kabasakal, Levant ;
Konijnenberg, Mark ;
Kopka, Klaus ;
Lassmann, Michael ;
Mottaghy, Felix M. ;
Oyen, Wim ;
Rahbar, Kambiz ;
Schoder, Heiko ;
Virgolini, Irene ;
Wester, Hans-Juergen ;
Bodei, Lisa ;
Fanti, Stefano ;
Haberkorn, Uwe ;
Herrmann, Ken .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2019, 46 (12) :2536-2544
[8]   Prostate cancer liver metastasis: Dormancy and resistance to therapy [J].
Ma, Bo ;
Wells, Alan ;
Wei, Liang ;
Zheng, Junnian .
SEMINARS IN CANCER BIOLOGY, 2021, 71 :2-9
[9]   Isolated Liver Metastasis Detected by 68Ga-PSMA PET/CT in Newly Diagnosed Prostate Cancer [J].
Onner, Hasan ;
Ozer, Halil ;
Celik, Ahmet Volkan ;
Yilmaz, Farise ;
Kara Gedik, Gonca .
CLINICAL NUCLEAR MEDICINE, 2023, 48 (03) :259-260
[10]   Additional Local Therapy for Liver Metastases in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Systemic PSMA-Targeted Therapy [J].
Seifert, Robert ;
Kessel, Katharina ;
Boegemann, Martin ;
Koehler, Michael ;
Roll, Wolfgang ;
Stegger, Lars ;
Weckesser, Matthias ;
Rahbar, Kambiz .
JOURNAL OF NUCLEAR MEDICINE, 2020, 61 (05) :723-728
12