Whole process establishment of carrier-free 177Lu production: from small-scale production to pilot-scale production

被引：4
|
作者：
Yang, Yuchuan [1 ,2 ]
Kan, Wentao [2 ]
Zhuo, Liangang [2 ]
Liu, Xiaojing [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Nucl Sci & Engn, Dong Chuan Rd 800, Shanghai 200240, Peoples R China
[2] China Acad Engn Phys, Inst Nucl Phys & Chem, Mianyang 621999, Sichuan, Peoples R China
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2023年 / 332卷 / 12期
关键词：
Carrier-free; Lu-177; Production; Small-scale; Pilot-scale; Quality control; SEPARATION;
D O I：
10.1007/s10967-023-09210-x
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this research, whole process of small-scale and pilot-scale carrier-free( 177)Lu production have been developed and curie-level Lu-177 was achieved. Additionally, the methodology of product key quality control inspection has been developed and verified, the control standard has been established. Key indicators of the product have met or exceeded the requirements of the European Pharmacopoeia. Up to date, about 30 Ci carrier-free Lu-177 product has been obtained based on this development. The carrier-free Lu-177 obtained in this research has been used in nearly 20 trial parties including units for drug R & D and clinical research.
引用
收藏
页码：4917 / 4928
页数：12
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