The burden of chronic drug-refractory focal onset epilepsy: Can it be prevented?

被引：9
作者：
Ben-Menachem, Elinor [1 ,7 ]
Schmitz, Bettina [2 ]
Kalviainen, Reetta [3 ]
Thomas, Rhys H. [4 ,5 ]
Klein, Pavel [6 ]
机构：
[1] Univ Gothenburg, Gothenburg, Sweden
[2] Vivantes Humboldt Hosp, Neurol Ctr Epilepsy, Stroke Unit & Neurol Rehabil, Berlin, Germany
[3] Univ Eastern Finland, Kuopio, Finland
[4] Royal Victoria Infirm, Dept Neurol, Queen Victoria Rd, Newcastle Upon Tyne NE1 4LP, England
[5] Translat & Clin Res Inst, Henry Wellcome Bldg,Framlington Pl, Newcastle Upon Tyne NE2 4HH, England
[6] George Washington Univ, Dept Neurol, Washington, DC USA
[7] Univ Gothenburg, Box 100, S-40530 Gothenburg, Sweden
来源：
EPILEPSY & BEHAVIOR | 2023年 / 148卷
关键词：
Drug -resistant epilepsy (DRE); Focal onset seizures; Quality of life (QoL); Burden of disease; Add-on; Third generation antiseizure medications (ASMs); QUALITY-OF-LIFE; RESISTANT EPILEPSY; ANTIEPILEPTIC DRUGS; ADJUNCTIVE CENOBAMATE; ILAE COMMISSION; EFFICACY; OUTCOMES; LACOSAMIDE; CHALLENGES; MANAGEMENT;
D O I：
10.1016/j.yebeh.2023.109435
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Despite the many therapeutic options for epilepsy available today, a third of patients still have poorly controlled epilepsy. Over the years, their transition through lines of treatment exposes them to increased risk of disease progression, mortality, morbidity, mental distress, and not least significantly impaired quality of life (QoL).The present review explores the multiple factors contributing to the impairment of health-related QoL in PWE-including both seizure-related and non seizure-related. The analysis aims to identify potential areas of intervention and strategies for a more holistic approach to epilepsy care and inform policymakers and healthcare providers in their approach to this condition.(c) 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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页数：9
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