LncRNAs: the good, the bad, and the unknown

被引：12

作者：

Arunkumar, Ganesan ^{[1
]}

机构：

[1] Univ New Mexico, Sch Med, Dept Cell Biol & Physiol, LncRNA Epigenet & Genome Org Lab, Albuquerque, NM 87131 USA

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2024年 / 102卷 / 01期

关键词：

LncRNAs; non-coding RNAs; epigenetics; genome organization; LONG-NONCODING RNA; X-CHROMOSOME INACTIVATION; GENE-EXPRESSION; CENP-A; CENTROMERIC DNA; NUCLEAR LAMINA; CANCER-CELLS; TUMOR-GROWTH; STEM-CELLS; XIST RNA;

D O I：

10.1139/bcb-2023-0155

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long non-coding RNAs (lncRNAs) are significant contributors in maintaining genomic integrity through epigenetic regulation. LncRNAs can interact with chromatin-modifying complexes in both cis and trans pathways, drawing them to specific genomic loci and influencing gene expression via DNA methylation, histone modifications, and chromatin remodeling. They can also operate as building blocks to assemble different chromatin-modifying components, facilitating their interactions and gene regulatory functions. Deregulation of these molecules has been associated with various human diseases, including cancer, cardiovascular disease, and neurological disorders. Thus, lncRNAs are implicated as potential diagnostic indicators and therapeutic targets. This review discusses the current understanding of how lncRNAs mediate epigenetic control, genomic integrity, and their putative functions in disease pathogenesis.

引用

页码：9 / 27

页数：19

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