IL-33/ST2 Signaling in the Pathogenesis of Chronic Pain and Itch

被引：4

作者：

Gao, Tian-Chi

Wang, Cheng-Hao

Wang, Yan-Qing

Mi, Wen-Li

机构：

[1] Fudan Univ, Inst Integrat Med,State Key Lab Med Neurobiol, Shanghai Med Coll,Shanghai Key Lab Acupuncture Me, Sch Basic Med Sci,Dept Integrat Med & Neurobiol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Inst Brain Sci, Shanghai Med Coll, MOE Frontiers Ctr Brain Sci, Shanghai 200032, Peoples R China

来源：

NEUROSCIENCE | 2023年 / 529卷

关键词：

interleukin-33; ST2; chronic pain; chronic pruritus; ARM VIBRATION SYNDROME; INFLAMMATORY PAIN; NEUROPATHIC PAIN; SENSORY NEURONS; INTERLEUKIN; 33; ST2; CONTRIBUTES; CYTOKINE; RECEPTOR; CELLS;

D O I：

10.1016/j.neuroscience.2023.08.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

(IL-33) is an inflammatory factor with an extensive range of biological effects and pleiotropic roles in diseases. Evidence suggests that IL-33 and its receptor ST2 play a pivotal role in chronic pain and itch at the level of primary sensory neurons, the spinal cord, and the brain. In this review, we outline an evolving understanding of the roles and mechanisms of IL-33 in chronic pathological pain, including inflammatory, neuropathic, and cancer, and chronic pruritus, such as allergic contact dermatitis, atopic dermatitis, and dry skin. Understanding the key roles of IL-33/ST2 signaling may provide exciting insights into the mechanisms of chronic pain and itch and lead to new clues for therapeutic approaches to the resolution of chronic pain and itch.& COPY; 2023 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：16 / 22

页数：7

共 51 条

[11] IL-33/ST2 signaling boosts inflammation and pain
Fattori, Victor
Borghi, Sergio M.
Verri, Waldiceu A., Jr.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (47) : E10034 - E10035
[12] Osteoarthritis
Glyn-Jones, S.
Palmer, A. J. R.
Agricola, R.
Price, A. J.
Vincent, T. L.
Weinans, H.
Carr, A. J.
[J]. LANCET, 2015, 386 (9991) : 376 - 387
[13] INTERLEUKIN-33 MEDIATES FORMALIN-INDUCED INFLAMMATORY PAIN IN MICE
Han, P.
Zhao, J.
Liu, S. -B.
Yang, C. -J.
Wang, Y. -Q.
Wu, G. -C.
Xu, D. -M.
Mi, W. -L.
[J]. NEUROSCIENCE, 2013, 241 : 59 - 66
[14] Inhibition of Spinal Interlukin-33/ST2 Signaling and Downstream ERK and JNK Pathways in Electroacupuncture Analgesia in Formalin Mice
Han, Ping
Liu, Shenbin
Zhang, Mengting
Zhao, Jing
Wang, Yanqing
Wu, Gencheng
Mi, Wenli
[J]. PLOS ONE, 2015, 10 (06):
[15] Hand-arm vibration syndrome: Workers' experience with functional impairment and disability
Handford, Midori
Lepine, Kiera
Boccia, Kristina
Ruddick, Francesca
Alyeksyeyeva, Darya
Thompson, Aaron
Holness, D. Linn
Switzer-McIntyre, Sharon
[J]. JOURNAL OF HAND THERAPY, 2017, 30 (04) : 491 - 499
[16] Blockade of IL-33 signalling attenuates osteoarthritis
He, Zengliang
Song, Yan
Yi, Yongxiang
Qiu, Fengzhuo
Wang, Junhua
Li, Junwei
Jin, Qingwen
Sacitharan, Pradeep Kumar
[J]. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2020, 9 (10)
[17] The effect of hand-arm vibration syndrome on quality of life
House, R.
Wills, M.
Liss, G.
Switzer-McIntyre, S.
Lander, L.
Jiang, D.
[J]. OCCUPATIONAL MEDICINE-OXFORD, 2014, 64 (02): : 133 - 135
[18] Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk
Huang, Junting
Gandini, Maria A.
Chen, Lina
M'Dahoma, Said
Stemkowski, Patrick L.
Chung, Hyunjae
Muruve, Daniel A.
Zamponi, Gerald W.
[J]. CELL REPORTS, 2020, 33 (01):
[19] Inhibition of Spinal Interleukin-33 Attenuates Peripheral Inflammation and Hyperalgesia in Experimental Arthritis
Huang, Si-Jian
Zhou, Lu-Yao
Ren, Fei
Zou, Wang-Yuan
Yan, Jian-Qin
Luo, Jian-Gang
[J]. MOLECULAR NEUROBIOLOGY, 2022, 59 (04) : 2246 - 2257
[20] IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation
Huang, Si-Jian
Yan, Jian-Qin
Luo, Hui
Zhou, Lu-Yao
Luo, Jian-Gang
[J]. JOURNAL OF NEUROINFLAMMATION, 2018, 15

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