Estimates of Drug Metabolism Using Drug Excretion Concentrations

被引：0

作者：

Cua, Agnes ^{[1
]}

Krock, Kevin ^{[1
]}

Thomas, Richard ^{[1
]}

Pesce, Amadeo ^{[1
]}

机构：

[1] Precis Diagnost LLC, San Diego, CA USA

来源：

ANNALS OF CLINICAL AND LABORATORY SCIENCE | 2023年 / 53卷 / 03期

关键词：

First order; Zero order; Drug metabolism; Urine drug concentrations; Metabolite parent drug ratio;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for these drugs.

引用

页码：460 / 468

页数：9

共 14 条

[1] Urinary Hydrocodone and Metabolite Distributions in Pain Patients [J].