Robotic in situ bioprinting for cartilage tissue engineering

被引:22
作者
Wang, Yaxin [1 ]
Pereira, Ruben F. [2 ,3 ,4 ]
Peach, Chris [5 ]
Huang, Boyang [6 ]
Vyas, Cian [1 ,6 ]
Bartolo, Paulo [1 ,6 ]
机构
[1] Univ Manchester, Dept Mech Aerosp & Civil Engn, Manchester M3 9PL, England
[2] Univ Porto, Inst Ciencias Biomed Abel Salazar, P-4050313 Porto, Portugal
[3] Univ Porto, Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal
[4] Univ Porto, Inst Engn Biomed, P-4200135 Porto, Portugal
[5] Manchester Univ NHS Fdn Trust, Manchester, England
[6] Nanyang Technol Univ, Singapore Ctr 3D Printing, Sch Mech & Aerosp Engn, Singapore 639798, Singapore
基金
英国工程与自然科学研究理事会;
关键词
in situ bioprinting; cartilage tissue engineering; robotic in situ bioprinting; minimally invasive surgery; bioinks; TOTAL KNEE ARTHROPLASTY; AUTOLOGOUS CHONDROCYTE IMPLANTATION; ARTICULAR-CARTILAGE; GROWTH-FACTOR; BIOMEDICAL APPLICATIONS; MECHANICAL-PROPERTIES; HOSPITAL DISCHARGE; CONTACT PRESSURE; PARTICLE-SIZE; STEM-CELLS;
D O I
10.1088/2631-7990/acda67
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in significant pain, mobility issues, and disability. Current surgical treatments have a limited capacity for efficacious cartilage repair, and long-term patient outcomes are not satisfying. Three-dimensional bioprinting has been used to fabricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue regeneration. However, conventional in vitro bioprinting has limitations due to the challenges associated with the fabrication and implantation of bioprinted constructs and their integration with the native cartilage tissue. In situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional bioprinting. In this review, we focus on the new frontier of robotic-assisted in situ bioprinting surgical systems for cartilage regeneration. We outline existing clinical approaches and the utilization of robotic-assisted surgical systems. Handheld and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are defined and presented. Finally, we discuss the challenges and potential future perspectives of in situ bioprinting for cartilage applications.
引用
收藏
页数:25
相关论文
共 214 条
  • [1] Biomaterials for In Situ Tissue Regeneration: A Review
    Abdulghani, Saba
    Mitchell, Geoffrey R.
    [J]. BIOMOLECULES, 2019, 9 (11)
  • [2] Direct-write 3D printing and characterization of a GelMA-based biomaterial for intracorporeal tissue
    Adib, A. Asghari
    Sheikhi, A.
    Shahhosseini, M.
    Simeunovic, A.
    Wu, S.
    Castro, C. E.
    Zhao, R.
    Khademhosseini, A.
    Hoelzle, D. J.
    [J]. BIOFABRICATION, 2020, 12 (04)
  • [3] In Situ Bioprinting of Autologous Skin Cells Accelerates Wound Healing of Extensive Excisional Full-Thickness Wounds
    Albanna, Mohammed
    Binder, Kyle W.
    Murphy, Sean V.
    Kim, Jaehyun
    Qasem, Shadi A.
    Zhao, Weixin
    Tan, Josh
    El-Amin, Idris B.
    Dice, Dennis D.
    Marco, Julie
    Green, Jason
    Xu, Tao
    Skardal, Aleksander
    Holmes, James H.
    Jackson, John D.
    Atala, Anthony
    Yoo, James J.
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [4] Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs
    Antich, Cristina
    de Vicente, Juan
    Jimenez, Gema
    Chocarro, Carlos
    Carrillo, Esmeralda
    Montanez, Elvira
    Galvez-Martin, Patricia
    Antonio Marchal, Juan
    [J]. ACTA BIOMATERIALIA, 2020, 106 : 114 - 123
  • [5] Cartilage immunoprivilege depends on donor source and lesion location
    Arzi, B.
    DuRaine, G. D.
    Lee, C. A.
    Huey, D. J.
    Borjesson, D. L.
    Murphy, B. G.
    Hu, J. C. Y.
    Baumgarth, N.
    Athanasiou, K. A.
    [J]. ACTA BIOMATERIALIA, 2015, 23 : 72 - 81
  • [6] Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs
    Ashammakhi, N.
    Ahadian, S.
    Xu, C.
    Montazerian, H.
    Ko, H.
    Nasiri, R.
    Barros, N.
    Khademhosseini, A.
    [J]. MATERIALS TODAY BIO, 2019, 1
  • [7] Athanasiou K A., 2016, Articular Cartilage, V2nd
  • [8] Robotic arm-assisted versus conventional medial unicompartmental knee arthroplasty: five-year clinical outcomes of a randomized controlled trial
    Banger, M.
    Doonan, J.
    Rowe, P.
    Jones, B.
    MacLean, A.
    Blyth, M. J. B.
    [J]. BONE & JOINT JOURNAL, 2021, 103B (06) : 1088 - 1095
  • [9] Protective effects of reactive functional groups on chondrocytes in photocrosslinkable hydrogel systems
    Bartnikowski, M.
    Bartnikowski, N. J.
    Woodruff, M. A.
    Schrobback, K.
    Klein, T. J.
    [J]. ACTA BIOMATERIALIA, 2015, 27 : 66 - 76
  • [10] 3D bioprinting: Materials, processes, and applications
    Bartolo, Paulo
    Malshe, Ajay
    Ferraris, Eleonora
    Koc, Bahattin
    [J]. CIRP ANNALS-MANUFACTURING TECHNOLOGY, 2022, 71 (02) : 577 - 597