Western Diet Causes Heart Failure With Reduced Ejection Fraction and Metabolic Shifts After Diastolic Dysfunction and Novel Cardiac Lipid Derangements

被引：25

作者：

Maurya, Santosh K. ^{[1
]}

Carley, Andrew N. ^{[1
]}

Maurya, Chandan K. ^{[1
]}

Lewandowski, E. Douglas ^{[1
,2
]}

机构：

[1] Ohio State Univ, Dept Internal Med, Coll Med, Columbus, OH USA

[2] Ohio State Univ, Coll Med, Biomed Res Tower,BRT Rm 312,460 West 12th Ave, Columbus, OH 43210 USA

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2023年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HFpEF; HFrEF; metabolism; triglyceride turnover; Western diet; HIGH-FAT DIET; CONTRACTILE DYSFUNCTION; TRIACYLGLYCEROL TURNOVER; INSULIN-RESISTANCE; ENERGY-METABOLISM; ACTIVATION; OXIDATION; CARDIOMYOPATHY; EFFICIENCY; LIPOLYSIS;

D O I：

10.1016/j.jacbts.2022.10.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Western diet (WD) impairs glucose tolerance and cardiac lipid dynamics, preceding heart failure with reduced ejection fraction (HFrEF) in mice. Unlike diabetic db/db mice with high cardiac triglyceride (TG) and rapid TG turnover, WD mice had high TG but slowed turnover, reducing lipolytic PPAR. activation. WD deranged cardiac TG dynamics by imbalancing synthesis and lipolysis, with low cardiac TG lipase (ATGL), low ATGL co-activator, and high ATGL inhibitory peptide. By 24 weeks of WD, hearts shifted from diastolic dysfunction to diastolic dysfunction with HFrEF with decreases in GLUT4 and exogenous glucose oxidation and elevated beta-hydroxybutyrate dehydrogenase 1 without increasing ketone oxidation. (J Am Coll Cardiol Basic Trans Science 2023;8:422- 435) (c) 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：422 / 435

页数：14

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