Prevalence of SARS-CoV-2 Viremia in Presymptomatic Blood Donors in the Delta and Omicron Variant Eras

被引：6

作者：

Saa, Paula ^{[1
]}

Fink, Rebecca, V ^{[2
]}

Dawar, Hina ^{[3
]}

Di Germanio, Clara ^{[3
,4
]}

Montalvo, Leilani ^{[3
]}

Wright, David J. ^{[2
]}

Krysztof, David E. ^{[1
]}

Kleinman, Steven H. ^{[5
]}

Nester, Theresa ^{[6
]}

Kessler, Debra A. ^{[7
]}

Townsend, Rebecca L. ^{[1
]}

Spencer, Bryan R. ^{[1
]}

Kamel, Hany ^{[8
]}

Vannoy, Jackie ^{[8
]}

Busch, Michael P. ^{[3
,4
]}

Stramer, Susan L. ^{[1
]}

Stone, Mars ^{[3
,4
]}

Norris, Philip J. ^{[3
,4
,9
]}

机构：

[1] Amer Red Cross, Sci Affairs, Rockville, MD USA

[2] Westat Corp, Rockville, MD USA

[3] Vitalant Res Inst, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA USA

[5] Univ British Columbia, Victoria, BC, Canada

[6] Bloodworks Northwest, Seattle, WA USA

[7] New York Blood Ctr Enterprises, New York, NY USA

[8] Vitalant, Scottsdale, AZ USA

[9] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2023年 / 10卷 / 05期

关键词：

COVID-19; vaccination; viremia; HEPATITIS-B; RESPONSES; CYTOKINE;

D O I：

10.1093/ofid/ofad253

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Presymptomatic plasma samples from 1596 donors reporting coronavirus disease 2019 infection or symptoms after blood donation were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA and anti-S and anti-N antibodies. Prior infection and vaccination both protected from developing SARS-CoV-2 RNAemia and from symptomatic infection. RNAemia rates did not differ in the Delta and Omicron variant eras.

引用

页数：5

共 14 条

[1] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[2] Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19 [J].

Bermejo-Martin, Jesus F. ;

Gonzalez-Rivera, Milagros ;

Almansa, Raquel ;

Micheloud, Dariela ;

Tedim, Ana P. ;

Dominguez-Gil, Marta ;

Resino, Salvador ;

Martin-Fernandez, Marta ;

Ryan Murua, Pablo ;

Perez-Garcia, Felipe ;

Tamayo, Luis ;

Lopez-Izquierdo, Raul ;

Bustamante, Elena ;

Aldecoa, Cesar ;

Manuel Gomez, Jose ;

Rico-Feijoo, Jesus ;

Orduna, Antonio ;

Mendez, Raul ;

Fernandez Natal, Isabel ;

Megias, Gregoria ;

Gonzalez-Estecha, Montserrat ;

Carriedo, Demetrio ;

Doncel, Cristina ;

Jorge, Noelia ;

Ortega, Alicia ;

de la Fuente, Amanda ;

del Campo, Felix ;

Antonio Fernandez-Ratero, Jose ;

Trapiello, Wysali ;

Gonzalez-Jimenez, Paula ;

Ruiz, Guadalupe ;

Kelvin, Alyson A. ;

Ostadgavahi, Ali Toloue ;

Oneizat, Ruth ;

Maria Ruiz, Luz ;

Miguens, Iria ;

Gargallo, Esther ;

Munoz, Ioana ;

Pelegrin, Sara ;

Martin, Silvia ;

Garcia Olivares, Pablo ;

Antonio Cedeno, Jamil ;

Ruiz Albi, Tomas ;

Puertas, Carolina ;

Angel Berezo, Jose ;

Renedo, Gloria ;

Herran, Ruben ;

Bustamante-Munguira, Juan ;

Enriquez, Pedro ;

Cicuendez, Ramon .

CRITICAL CARE, 2020, 24 (01)

[3]

Centers for Disease Control and Prevention, SARS COV 2 VAR PROP

[4] Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019 [J].

Chen, Xiaohua ;

Zhao, Binghong ;

Qu, Yueming ;

Chen, Yurou ;

Xiong, Jie ;

Feng, Yong ;

Men, Dong ;

Huang, Qianchuan ;

Liu, Ying ;

Yang, Bo ;

Ding, Jinya ;

Li, Feng .

CLINICAL INFECTIOUS DISEASES, 2020, 71 (08) :1937-1942

[5] SARS-CoV-2 antibody persistence in COVID-19 convalescent plasma donors: Dependency on assay format and applicability to serosurveillance [J].

Di Germanio, Clara ;

Simmons, Graham ;

Kelly, Kathleen ;

Martinelli, Rachel ;

Darst, Orsolya ;

Azimpouran, Mahzad ;

Stone, Mars ;

Hazegh, Kelsey ;

Grebe, Eduard ;

Zhang, Shuting ;

Ma, Peijun ;

Orzechowski, Marek ;

Gomez, James E. ;

Livny, Jonathan ;

Hung, Deborah T. ;

Vassallo, Ralph ;

Busch, Michael P. ;

Dumont, Larry J. .

TRANSFUSION, 2021, 61 (09) :2677-2687

[6] SARS-CoV-2 viral load is associated with increased disease severity and mortality [J].

Fajnzylber, Jesse ;

Regan, James ;

Coxen, Kendyll ;

Corry, Heather ;

Wong, Colline ;

Rosenthal, Alexandra ;

Worrall, Daniel ;

Giguel, Francoise ;

Piechocka-Trocha, Alicja ;

Atyeo, Caroline ;

Fischinger, Stephanie ;

Chan, Andrew ;

Flaherty, Keith T. ;

Hall, Kathryn ;

Dougan, Michael ;

Ryan, Edward T. ;

Gillespie, Elizabeth ;

Chishti, Rida ;

Li, Yijia ;

Jilg, Nikolaus ;

Hanidziar, Dusan ;

Baron, Rebecca M. ;

Baden, Lindsey ;

Tsibris, Athe M. ;

Armstrong, Katrina A. ;

Kuritzkes, Daniel R. ;

Alter, Galit ;

Walker, Bruce D. ;

Yu, Xu ;

Li, Jonathan Z. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[7] Severe Acute Respiratory Syndrome Coronavirus 2 Viremia Is Associated With Coronavirus Disease 2019 Severity and Predicts Clinical Outcomes [J].

Jacobs, Jana L. ;

Bain, William ;

Naqvi, Asma ;

Staines, Brittany ;

Castanha, Priscila M. S. ;

Yang, Haopu ;

Boltz, Valerie F. ;

Barratt-Boyes, Simon ;

Marques, Ernesto T. A. ;

Mitchell, Stephanie L. ;

Methe, Barbara ;

Olonisakin, Tolani F. ;

Haidar, Ghady ;

Burke, Thomas W. ;

Petzold, Elizabeth ;

Denny, Thomas ;

Woods, Chris W. ;

McVerry, Bryan J. ;

Lee, Janet S. ;

Watkins, Simon C. ;

St Croix, Claudette M. ;

Morris, Alison ;

Kearney, Mary F. ;

Ladinsky, Mark S. ;

Bjorkman, Pamela J. ;

Kitsios, Georgios D. ;

Mellors, John W. .

CLINICAL INFECTIOUS DISEASES, 2022, 74 (09) :1525-1533

[8] Cytokine and Chemokine Responses in the Acute Phase of Hepatitis B Virus Replication in Naive and Previously Vaccinated Blood and Plasma Donors [J].

Keating, Sheila M. ;

Heitman, John D. ;

Wu, Shiquan ;

Deng, Xutao ;

Stramer, Susan L. ;

Kuhns, Mary C. ;

Mullen, Carolyn ;

Norris, Philip J. ;

Busch, Michael P. .

JOURNAL OF INFECTIOUS DISEASES, 2014, 209 (06) :845-854

[9] Identification and characterisation of transmitted and early founder virus envelopes in primary HIV-1 infection [J].

Keele, Brandon F. ;

Giorgi, Elena E. ;

Salazar-Gonzalez, Jesus F. ;

Decker, Julie M. ;

Pham, Kimmy T. ;

Salazar, Maria G. ;

Sun, Chuanxi ;

Grayson, Truman ;

Wang, Shuyi ;

Li, Hui ;

Wei, Xiping ;

Jiang, Chunlai ;

Kirchherr, Jennifer L. ;

Gao, Feng ;

Anderson, Jeffery A. ;

Ping, Li-Hua ;

Swanstrom, Ronald ;

Tomaras, Georgia D. ;

Blattner, William A. ;

Goepfert, Paul A. ;

Kilby, J. Michael ;

Saag, Michlael S. ;

Delwart, Eric L. ;

Busch, Michael P. ;

Cohen, Myron S. ;

Montefiori, David C. ;

Haynes, Barton F. ;

Gaschen, Brian ;

Athreya, Gayathri S. ;

Lee, Ha Y. ;

Wood, Natasha ;

Seoighe, Cathal ;

Perelson, Alan S. ;

Bhattacharya, Tanmoy ;

Korber, Bette T. ;

Hahn, Beatrice H. ;

Shaw, George M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (21) :7552-7557

[10] Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine [J].

Polack, Fernando P. ;

Thomas, Stephen J. ;

Kitchin, Nicholas ;

Absalon, Judith ;

Gurtman, Alejandra ;

Lockhart, Stephen ;

Perez, John L. ;

Perez Marc, Gonzalo ;

Moreira, Edson D. ;

Zerbini, Cristiano ;

Bailey, Ruth ;

Swanson, Kena A. ;

Roychoudhury, Satrajit ;

Koury, Kenneth ;

Li, Ping ;

Kalina, Warren V. ;

Cooper, David ;

Frenck, Robert W., Jr. ;

Hammitt, Laura L. ;

Tureci, Ozlem ;

Nell, Haylene ;

Schaefer, Axel ;

Unal, Serhat ;

Tresnan, Dina B. ;

Mather, Susan ;

Dormitzer, Philip R. ;

Sahin, Ugur ;

Jansen, Kathrin U. ;

Gruber, William C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) :2603-2615

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