Hungry for control: metabolite signaling to chromatin in Plasmodium falciparum

被引：1
作者：
Lappalainen, Ruth [1 ]
Kumar, Manish [1 ]
Duraisingh, Manoj [1 ]
机构：
[1] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
来源：
CURRENT OPINION IN MICROBIOLOGY | 2024年 / 78卷
基金：
美国国家卫生研究院;
关键词：
HISTONE ADP-RIBOSYLATION; GENE-EXPRESSION; CYCLE; CROTONYLATION; TRANSCRIPTION; METHYLATION; DEACETYLASE; RESPONSES; PATHWAYS; SIRTUIN;
D O I：
10.1016/j.mib.2024.102430
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The human malaria parasite Plasmodium falciparum undergoes a complex life cycle in two hosts, mammalian and mosquito, where it is constantly subjected to environmental changes in nutrients. Epigenetic mechanisms govern transcriptional switches and are essential for parasite persistence and proliferation. Parasites infecting red blood cells are auxotrophic for several nutrients, and mounting evidence suggests that various metabolites act as direct substrates for epigenetic modifications, with their abundance directly relating to changes in parasite gene expression. Here, we review the latest understanding of metabolic changes that alter the histone code resulting in changes to transcriptional programmes in malaria parasites.
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页数：9
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