Projected Life Expectancy Gains From Improvements in HIV Care in Black and White Men Who Have Sex With Men

被引:3
作者
Rich, Katherine M. [2 ,3 ]
Pandya, Ankur [4 ]
Chiosi, John J. [2 ,3 ,5 ]
Reddy, Krishna P. [2 ,3 ,6 ,7 ]
Shebl, Fatma M. [2 ,3 ]
Ciaranello, Andrea L. [2 ,3 ,5 ]
Neilan, Anne M. [2 ,3 ,5 ,8 ]
Pinkney, Jodian A. [2 ,3 ,5 ]
Losina, Elena [3 ,9 ,10 ,11 ]
Freedberg, Kenneth A. [2 ,3 ,4 ,5 ,12 ,13 ]
Ahonkhai, Aima A. [2 ,5 ,13 ,14 ,15 ]
Hyle, Emily P. [1 ,2 ,3 ,5 ,13 ]
机构
[1] Massachusetts Gen Hosp, Div Infect Dis, 100 Cambridge St,16th Floor, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Med Practice Evaluat Ctr MPEC, Boston, MA 02114 USA
[3] Harvard Med Sch, Boston, MA USA
[4] Harvard TH Chan Sch Publ Hlth, Dept Hlth Policy & Management, Boston, MA USA
[5] Massachusetts Gen Hosp, Dept Med, Div Infect Dis, Boston, MA 02114 USA
[6] Massachusetts Gen Hosp, Tobacco Res & Treatment Ctr, Boston, MA 02114 USA
[7] Massachusetts Gen Hosp, Div Pulm & Crit Care Med, Boston, MA 02114 USA
[8] Massachusetts Gen Hosp, Div Gen Acad Pediat, Boston, MA 02114 USA
[9] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
[10] Brigham & Womens Hosp, Orthoped & Arthrit Ctr Outcomes Res OrACORe, Dept Orthoped Surg, Boston, MA 02130 USA
[11] Brigham & Womens Hosp, Policy & Innovat Evaluat Orthoped Treatments PIVOT, Dept Orthoped Surg, Boston, MA USA
[12] Massachusetts Gen Hosp, Dept Med, Div Gen Internal Med, Boston, MA 02114 USA
[13] Harvard Univ, Harvard Univ Ctr AIDS Res, Boston, MA USA
[14] Vanderbilt Univ, Med Ctr, Dept Med, Infect Dis, Nashville, TN USA
[15] Vanderbilt Univ, Med Ctr, Vanderbilt Inst Global Hlth, Nashville, TN USA
关键词
NATIONAL HIV/AIDS STRATEGY; COST-EFFECTIVENESS; CIGARETTE-SMOKING; UNITED-STATES; HEALTH; DISPARITIES; RECOMMENDATIONS; ADOLESCENTS; PREVALENCE; INFECTION;
D O I
10.1001/jamanetworkopen.2023.44385
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
IMPORTANCE Substantial racial inequities exist across the HIV care continuum between non-Hispanic Black and White men who have sex with men (MSM) in the US.OBJECTIVES To project years of life gained (YLG) with improving the HIV care continuum among Black MSM and White MSM in the US and to determine the outcomes of achieving health equity goals.DESIGN, SETTING, AND PARTICIPANTS The Cost-Effectiveness of Preventing AIDS Complications microsimulation model was used and populated with 2021 race-specific data to simulate HIV care among Black MSM and White MSM in the US who have acquired HIV. Analyses were completed from July 2021 to October 2023.INTERVENTION The study simulated status quo care using race-specific estimates: age at infection, time to diagnosis, receipt of care, and virologic suppression. The study next projected the outcomes of attaining equity-centered vs non-equity-centered goals by simulating 2 equal improvements in care goals: (10-point increased receipt of care and 5-point increased virologic suppression), 3 equity centered goals (annual HIV testing, 95% receiving HIV care, and 95% virologic suppression) and lastly, an equitable care continuum that achieves annual HIV testing, 95% receiving care, and 95% virologic suppression in Black MSM and White MSM. One-way and multiway sensitivity and scenario analyses were conducted.MAIN OUTCOMES AND MEASURES Mean age at death and YLG.RESULTS In the simulated cohort, the mean (SD) age at HIV infection was 27.0 (10.8) years for Black MSM and 35.5 (13.6) years for White MSM. In status quo, mean age at death would be 68.8 years for Black MSM and 75.6 years for White MSM. The equal improvements in care goals would result in 0.5 YLG for Black MSM and 0.5 to 0.9 YLG for White MSM. Achieving any 1 equity-centered goal would result in 0.5 to 1.7 YLG for Black MSM and 0.4 to 1.3 YLG for White MSM. With an equitable care continuum compared with the nationally reported status quo, Black MSM and White MSM would gain 3.5 and 2.1 life-years, respectively. If the status quo HIV testing was every 6 years with 75% retained in care and 75% virologically suppressed, Black MSM would gain 4.2 life-years with an equitable care continuum.CONCLUSIONS AND RELEVANCE In this simulation modeling study of HIV care goals, equal improvements in HIV care for Black and White MSM maintained or worsened inequities. These results suggest that equity-centered goals for the HIV care continuum are critical to mitigate longstanding inequities in HIV outcomes.
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页数:13
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