Derivatives of the closo-Decaborate Anion with Pendant Functional Groups as Inhibitors of Viral Replication

被引：11

作者：

Matveev, E. Yu. ^{[1
,2
]}

Garaev, T. M. ^{[3
]}

Novikov, S. S. ^{[1
]}

Nichugovskii, A. I. ^{[1
]}

Sokolov, I. E. ^{[1
]}

Larichev, V. F. ^{[3
]}

Lebedeva, V. V. ^{[3
]}

Grebennikova, T. V. ^{[3
]}

Avdeeva, V. V. ^{[2
]}

Malinina, E. A. ^{[2
]}

Zhizhin, K. Yu. ^{[1
,2
]}

Kuznetsov, N. T. ^{[2
]}

机构：

[1] Russian Technol Univ, Lomonosov Inst Fine Chem Technol, MIREA, Moscow 119571, Russia

[2] Russian Acad Sci, Kurnakov Inst Gen & Inorgan Chem, Moscow 119991, Russia

[3] Minist Hlth Russian Federat, Ntl Res Ctr Epidemiol & Microbiol, Moscow 123098, Russia

来源：

RUSSIAN JOURNAL OF INORGANIC CHEMISTRY | 2023年 / 68卷 / 06期

关键词：

boron cluster anions; opening of a cyclic substituent; closo-decaborates with a pendant functional group; coronavirus; rabies; influenza A; antiviral activity; NUCLEOPHILIC-ADDITION; OXONIUM DERIVATIVES; DODECABORATE ANION; THERMAL REDUCTION; IONIC LIQUIDS; COMPLEXES; N=10; N2H4; H2O; N=6;

D O I：

10.1134/S0036023623600533

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reaction between the 1,4-dioxane derivative of the closo-decaborate anion [2-B10H9O(CH2)(4)O]- with cyanide, hydrophthalate, and hydroiminoacetate ions has been studied. Alkali metal salts (K, Na, and Cs) of the closo-decaborate anion derivatives with pendant groups -NHCH2CH2NH2-, -OOC(o-C6H4)COOH-, -OOCCH2NHCH2COOH-, -OCH2CH2OH-, -CN-, -SCN-, and -SH- have been isolated. All compounds have been shown to have extremely low cytotoxicity (CT50 similar to 1000 mu g/mL). It has been found that compounds Na-2[B10H9O(CH2)(2)O(CH2)(2)SCN] and Na-2[B10H9O(CH2)(2)O(CH2)(2)CN] exhibit activity and selectivity in vitro against the modern strain of SARS-CoV-2 coronavirus (IC50 312 and 625 mu g/mL, respectively). In relation to influenza A virus and rabies virus, the compounds show weak antiviral activity at high concentrations (1250 mu g/mL), i.e. show no selective effect on the reproduction of these viruses.

引用

页码：670 / 677

页数：8

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