Modern drug discovery using ethnobotany: A large-scale cross-cultural analysis of traditional medicine reveals common therapeutic uses

被引：11

作者：

Domingo-Fernandez, Daniel ^{[1
]}

Gadiya, Yojana ^{[1
]}

Mubeen, Sarah ^{[1
]}

Bollerman, Thomas Joseph ^{[1
]}

Healy, Matthew D. ^{[1
]}

Chanana, Shaurya ^{[1
]}

Sadovsky, Rotem Gura ^{[1
]}

Healey, David ^{[1
]}

Colluru, Viswa ^{[1
]}

机构：

[1] Enveda Biosci, Boulder, CO 80301 USA

来源：

ISCIENCE | 2023年 / 26卷 / 09期

关键词：

ACUTE LUNG INJURY; TARAXACUM-OFFICINALE; PLANTS; EXTRACT;

D O I：

10.1016/j.isci.2023.107729

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

For millennia, numerous cultures and civilizations have relied on traditional remedies derived from plants to treat a wide range of conditions and ailments. Here, we systematically analyzed ethnobotanical patterns across taxonomically related plants, demonstrating that congeneric medicinal plants are more likely to be used for treating similar indications. Next, we reconstructed the phytochemical space covered by medicinal plants to reveal that (i) taxonomically related medicinal plants cover a similar phytochemical space, and (ii) chemical similarity correlates with similar therapeutic usage. Lastly, we present several case scenarios illustrating how mining this information can be used for drug discovery applications, including: (i) investigating taxonomic hotspots around particular indications, (ii) exploring shared patterns of congeneric plants located in different geographic areas, but which have been used to treat the same indications, and (iii) showing the concordance between ethnobotanical patterns among non-taxonomically related plants and the presence of shared bioactive phytochemicals.

引用

页数：15

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