Pathology and Treatment of Psoriasis Using Nanoformulations

被引:11
作者
Thirumal, Divya [1 ]
Sindhu, Rakesh K. [2 ]
Goyal, Shuchi [1 ]
Sehgal, Aayush [3 ]
Kumar, Ashok [4 ]
Babu, Marianesan Arockia [5 ]
Kumar, Pradeep [6 ]
机构
[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, Punjab, India
[2] Sharda Univ, Sch Pharm, Greater Noida 201310, Uttar Pradesh, India
[3] GHG Khalsa Coll Pharm, Dept Pharmacol, Ludhiana 141014, Punjab, India
[4] Sadbhwana Hosp, Dept Cardiol, Fatehabad 125050, Haryana, India
[5] GLA Univ, Inst Pharmaceut Res, Mathura 281406, Uttar Pradesh, India
[6] Univ Witwatersrand, Fac Hlth Sci, Sch Therapeut Sci, Dept Pharm & Pharmacol,Wits Adv Drug Delivery Plat, ZA-2193 Johannesburg, South Africa
关键词
psoriasis; bioactive; drug delivery system; nano formulations; therapies; TRANSDERMAL DRUG-DELIVERY; PHOTODYNAMIC THERAPY; LIPID NANOPARTICLES; SKIN; CHITOSAN; PATHOPHYSIOLOGY; INFLAMMATION; FORMULATIONS; PENETRATION; CARRIERS;
D O I
10.3390/biomedicines11061589
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Psoriasis (PSO) is an inflammatory skin condition that causes a variety of diseases and significantly decreases the life characteristics of patients, and substantially diminishes patients' quality of life. PSO usually impairs the skin and is linked to various disorders. Inflammation pathology does not only damage psoriatic skin; it shows how PSO impinges other body parts. Many variables interact with one another and can impact the etiology of psoriasis directly or indirectly. PSO has an effect on approximately 2% of the world's population, and significant progress has been made in comprehending and treating the alternative PSO by novel drug delivery systems. Topical, systemic, biological, biomaterials, and phototherapy are some of the useful therapies for PSO. Nonetheless, topical treatments remain the gold standard for treating moderate PSO. The applicability of several nanocarrier systems, such as lipid nanoparticles, metallic nanoparticles, and certain phytocompounds, has been briefly explored. The present review focuses mainly on traditional therapeutic strategies as well as on breakthroughs in nanoformulations and drug delivery methods for several anti-psoriatic drugs.
引用
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页数:19
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