Imidazole-carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

被引：12

作者：

Pham, Thanh Chung ^{[1
]}

Lee, Dong Joon ^{[2
]}

Kim, Do Hun ^{[3
]}

Yoon, Juyoung ^{[4
]}

Lam, Tran Dai ^{[1
]}

Kim, Hwan Myung ^{[2
,5
]}

Lee, Songyi ^{[3
,6
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Trop Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam

[2] Ajou Univ, Dept Chem, Suwon 16400, South Korea

[3] Pukyong Natl Univ, Ind Convergence Bion Engn 4 0, Pusan 48513, South Korea

[4] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea

[5] Ajou Univ, Dept Energy Syst Res, Suwon 16499, South Korea

[6] Pukyong Natl Univ, Dept Chem, Pusan 48513, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 30期

基金：

新加坡国家研究基金会;

关键词：

ATOM-FREE PHOTOSENSITIZERS; MOLECULAR DESIGN; CANCER; ABSORPTION;

D O I：

10.1039/d3cc00108c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A heavy-atom-free photosensitizer (CI) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.

引用

页码：4503 / 4506

页数：4

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