Role of Sex and Age in Fatal Outcomes of COVID-19: Women and Older Centenarians Are More Resilient

被引：15

作者：

Caruso, Calogero ^{[1
]}

Marcon, Gabriella ^{[2
,3
]}

Accardi, Giulia ^{[1
]}

Aiello, Anna ^{[1
]}

Calabro, Anna ^{[1
]}

Ligotti, Mattia Emanuela ^{[1
]}

Tettamanti, Mauro ^{[4
]}

Franceschi, Claudio ^{[5
]}

Candore, Giuseppina ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Biomed Neurosci & Diagnost Avanzata, Lab Immunopatol & Immunosenescenza, I-90134 Palermo, Italy

[2] Univ Trieste, Dipartimento Sci Med Chirurg & Salute, I-34149 Trieste, Italy

[3] Univ Udine, Dipartinento Area Med, I-33100 Udine, Italy

[4] Ist Ric Farmacol Mario Negri IRCCS, Lab Epidemiol Geriatr, I-20156 Milan, Italy

[5] Univ Bologna, Dipartimento Sci Med & Chirurg, Alma Mater Studiorum, I-40126 Bologna, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 03期

关键词：

age; COVID-19; immune responses; longevity; mortality; narrative review; sex; Spanish flu; INFLUENZA; GENDER;

D O I：

10.3390/ijms24032638

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present paper, we have analysed the role of age and sex in the fatal outcome of COVID-19, as there are conflicting results in the literature. As such, we have answered three controversial questions regarding this aspect of the COVID-19 pandemic: (1) Have women been more resilient than men? (2) Did centenarians die less than the remaining older people? (3) Were older centenarians more resistant to SARS-CoV-2 than younger centenarians? The literature review demonstrated that: (1) it is women who are more resilient, in agreement with data showing that women live longer than men even during severe famines and epidemics; however, there are conflicting data regarding centenarian men; (2) centenarians overall did not die less than remaining older people, likely linked to their frailty; (3) in the first pandemic wave of 2020, centenarians > 101 years old (i.e., born before 1919), but not "younger centenarians", have been more resilient to COVID-19 and this may be related to the 1918 Spanish flu epidemic, although it is unclear what the mechanisms might be involved.

引用

页数：12

共 62 条

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