State of art in the chemistry of nucleoside-based Pt(II) complexes

被引：4

作者：

D'Errico, Stefano ^{[1
]}

Falanga, Andrea Patrizia ^{[1
]}

Greco, Francesca ^{[1
]}

Piccialli, Gennaro ^{[1
]}

Oliviero, Giorgia ^{[2
]}

Borbone, Nicola ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, Via Domen Montesano 49, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Via Sergio Pansini 5, I-80131 Naples, Italy

来源：

BIOORGANIC CHEMISTRY | 2023年 / 131卷

关键词：

Nucleosides; Cisplatin; Pt(II) complexes; Anticancer drugs; Cancer; DNA; Chemotherapy; G-Quadruplex; SOLID-PHASE SYNTHESIS; DNA G-QUADRUPLEXES; PHARMACOLOGICAL EVALUATION; ANTIPROLIFERATIVE ACTIVITY; PLATINUM(II) COMPLEXES; X-RAY; DRUG; BINDING; ANTITUMOR; ANALOGS;

D O I：

10.1016/j.bioorg.2022.106325

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After the fortuitous discovery of the anticancer properties of cisplatin, many Pt(II) complexes have been synthesized, to obtain less toxic leads which could overcome the resistance phenomena. Given the importance of nucleosides and nucleotides as antimetabolites, studying their coordinating properties towards Pt(II) ions is challenging for bioorganic and medicinal chemistry. This review aims to describe the results achieved so far in the aforementioned field, paying particular attention to the synthetic aspects, the chemical-physical characterization, and the biological activities of the nucleoside-based Pt(II) complexes.

引用

页数：19

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