Degradation products of resin-based materials detected in saliva in vivo

被引：2

作者：

Vervliet, Philippe ^{[1
]}

De Nys, Siemon ^{[2
,3
]}

Duca, Radu Corneliu ^{[4
,5
]}

Boonen, Imke ^{[6
]}

Godderis, Lode ^{[4
]}

Elskens, Marc ^{[6
]}

Van Landuyt, Kirsten L. ^{[2
,3
]}

Covaci, Adrian ^{[1
]}

机构：

[1] Univ Antwerp, Toxicol Ctr, Univ pl 1, B-2610 Antwerp, Belgium

[2] Univ Leuven, BIOMAT, Dept Oral Hlth Sci, KU Leuven, Louvain, Belgium

[3] Univ Hosp Leuven UZ Leuven, Dent, Louvain, Belgium

[4] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Environm & Hlth, Kapucijnenvoer 35, B-3000 Louvain, Belgium

[5] Natl Hlth Lab LNS, Dept Hlth Protect, Environm Hyg & Human Biol Monitoring, 1 Rue Louis Rech, L-3555 Dudelange, Luxembourg

[6] Vrije Univ Brussel, Dept Analyt Environm & Geochem, Pleinlaan 2, B-1050 Ixelles, Belgium

来源：

CLINICAL ORAL INVESTIGATIONS | 2023年 / 27卷 / 12期

关键词：

Resin-based dental materials; In vivo; Leaching; Degradation; Saliva; Dental restorations; BISPHENOL-A; BULK-FILL; COMPOSITE; MONOMERS; RELEASE; RESTORATIONS; METABOLISM; AMALGAM; ELUTION; ETHERS;

D O I：

10.1007/s00784-023-05075-2

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

ObjectivesDental composites remain under scrutiny regarding their (long-term) safety. In spite of numerous studies on the release of monomers both in vitro and in vivo, only limited quantitative data exist on the in vivo leaching of degradation products from monomers and additives. The aim of this observational study was for the first time to quantitatively and qualitatively monitor the release of parent compounds and their degradation products in saliva from patients undergoing multiple restorations.Materials and methodsFive patients in need of multiple large composite restorations (minimally 5 up to 28 restorations) due to wear (attrition, abrasion, and erosion) were included in the study, and they received adhesive restorative treatment according to the standard procedures in the university clinic for Restorative Dentistry. Saliva was collected at different time points, starting before the restoration up until 24 h after the treatment with composite restorations. Saliva extracts were analyzed by liquid chromatography-mass spectrometry.ResultsLeaching of monomers and degradation products was highest within 30 min after the placement of the restorations. The highest median concentrations of monomers were recorded for UDMA, BisEMA-3, and TEGDMA; yet, besides BisEMA-3 and TEGDMA, no monomers could be detected after 24 h. Mono- and demethacrylated degradation products remained present up to 24 h and concentrations were generally higher than those of monomers. In patients with multiple restorations, degradation products were still present in the sample taken before the next operation, several weeks after the previous operation.ConclusionsExposure to residual monomers and degradation products occurs in the first hours after restoration. Monomers are present in saliva shortly after restoration, but degradation products can be detected weeks after the restoration confirming a long-term release.Clinical significanceFuture research should focus more on the release of degradation products from monomers and additives from resin-based materials given their prolonged presence in saliva after restoration.

引用

页码：7189 / 7198

页数：10

共 27 条

[1] Analysis of long-term monomer elution from bulk-fill and conventional resin-composites using high performance liquid chromatography [J].