An updated review of contribution of long noncoding RNA-NEAT1 to the progression of human cancers

被引:7
作者
Farzaneh, Maryam [1 ]
Masoodi, Tariq [2 ]
Ghaedrahmati, Farhoodeh [3 ]
Radoszkiewicz, Klaudia [4 ]
Anbiyaiee, Amir [5 ]
Sheykhi-Sabzehpoush, Mohadeseh [6 ]
Rad, Niloofar Khoshdel [7 ]
Uddin, Shahab [8 ,9 ]
Jooybari, Seyedeh Pardis Motiee [10 ]
Khoshnam, Seyed Esmaeil [11 ,12 ]
Azizidoost, Shirin [13 ]
机构
[1] Ahvaz Jundishapur Univ Med Sci, Fertil Infertil & Perinatol Res Ctr, Ahvaz, Iran
[2] Sidra Med, Canc Res Dept, Lab Mol & Metab Imaging, Doha, Qatar
[3] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran
[4] Polish Acad Sci, Mossakowski Med Res Inst, Translat Platform Regenerat Med, Warsaw, Poland
[5] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Surg, Ahvaz, Iran
[6] Univ Tehran Med Sci, Imam Khomeini Hosp Complex, epartment Lab, Tehran, Iran
[7] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Stem Cells & Dev Biol, Tehran, Iran
[8] Hamad Med Corp, Translat Res Inst, Doha, Qatar
[9] Hamad Med Corp, Dermatol Inst, Acad Hlth Syst, Doha, Qatar
[10] Univ Gonbad Kavous, Fac Basic Sci & Engn, Dept Biol, Gonbad Kavus, Golestan, Iran
[11] Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Cellular & Mol Res Ctr, Ahvaz, Iran
[12] Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Persian Gulf Physiol Res Ctr, Ahvaz, Iran
[13] Ahvaz Jundishapur Univ Med Sci, Atherosclerosis Res Ctr, Ahvaz, Iran
关键词
LncRNAs; NEAT1; Cancer; Tumorigenesis; Biomarker; RNA NEAT1 PROMOTES; IMPACTS CELL-PROLIFERATION; COMPETING ENDOGENOUS RNA; LNCRNA NEAT1; HEPATOCELLULAR-CARCINOMA; INHIBITS PROLIFERATION; DOWN-REGULATION; IN-VITRO; PROSTATE-CANCER; EMERGING ROLES;
D O I
10.1016/j.prp.2023.154380
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Long non-coding RNAs (lncRNAs) present pivotal roles in cancer tumorigenesis and progression. Recently, nuclear paraspeckle assembly transcript 1 (NEAT1) as a lncRNA has been shown to mediate cell proliferation, migration, and EMT in tumor cells. NEAT1 by targeting several miRNAs/mRNA axes could regulate cancer cell behavior. Therefore, NEAT1 may function as a potent biomarker for the prediction and treatment of some human cancers. In this review, we summarized various NEAT1-related signaling pathways that are critical in cancer initiation and progression.
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收藏
页数:17
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