Advances in development of exosomes for ophthalmic therapeutics

被引：25
作者：
Tian, Ying [1 ]
Zhang, Tao [1 ]
Li, Jing [2 ]
Tao, Yong [1 ]
机构：
[1] Capital Med Univ, Beijing Chaoyang Hosp, Dept Ophthalmol, Beijing 100020, Peoples R China
[2] Capital Normal Univ, Coll Life Sci, Beijing Key Lab DNA Damage Response, Beijing 100048, Peoples R China
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2023年 / 199卷
基金：
中国国家自然科学基金;
关键词：
Ophthalmic diseases; Exosome; Therapeutics; Delivery vector; MESENCHYMAL STEM-CELLS; DEXAMETHASONE INTRAVITREAL IMPLANT; VESICLES PROMOTE NEUROPROTECTION; CORNEAL ALLOGRAFT-REJECTION; DRUG-DELIVERY VEHICLES; EXTRACELLULAR VESICLES; MACULAR DEGENERATION; NONINFECTIOUS UVEITIS; VISUAL IMPAIRMENT; MEDIATED DELIVERY;
D O I：
10.1016/j.addr.2023.114899
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Exosomes contain multiple bioactive molecules and maintain the connection between cells. Recent advances in exosome-based therapeutics have witnessed unprecedented opportunities in treating ophthalmic diseases, including traumatic diseases, autoimmune diseases, chorioretinal diseases and others. Utilization of exosomes as delivery vectors to encapsulate both drugs and therapeutic genes could yield higher efficacy and avoid the unnecessary immune responses. However, exosome-based therapies also come with some potential ocular risks. In this review, we first present a general introduction to exosomes. Then we provide an overview of available applications and discuss their potential risks. Moreover, we review recently reported exosomes as delivery vectors for ophthalmic diseases. Finally, we put forward future perspectives to grapple with its translation and underlying issues.& COPY; 2023 Elsevier B.V. All rights reserved.
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页数：24
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