Hypertensive disorders of pregnancy and subsequent risk of Alzheimer's disease and other dementias

被引：8

作者：

Schliep, Karen C. ^{[1
,14
]}

Shaaban, C. Elizabeth ^{[2
]}

Meeks, Huong ^{[3
]}

Fraser, Alison ^{[3
]}

Smith, Ken R. ^{[4
]}

Majersik, Jennifer J. ^{[5
]}

Foster, Norman L. ^{[5
]}

Wactawski-Wende, Jean ^{[6
]}

ostbye, Truls ^{[7
]}

Tschanz, JoAnn ^{[8
]}

Padbury, James F. ^{[9
]}

Sharma, Surrendra ^{[10
]}

Zhang, Yue ^{[11
]}

Facelli, Julio C. ^{[12
]}

Abdelrahman, C. Samir

Theilen, Lauren ^{[13
]}

Varner, Michael W. ^{[13
]}

机构：

[1] Univ Utah, Dept Family & Preventat Med, Salt Lake City, UT USA

[2] Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

[3] Huntsman Canc Inst, Dept Populat Sci, Salt Lake City, UT USA

[4] Univ Utah, Dept Family & Consumer Studies, Salt Lake City, UT USA

[5] Univ Utah, Dept Neurol, Salt Lake City, UT USA

[6] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY USA

[7] Duke Univ, Community & Family Med & Community Hlth, Nursing & Global Hlth, Durham, NC USA

[8] Utah State Univ, Dept Psychol, Logan, UT USA

[9] Univ Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA USA

[10] Brown Univ, Women & Infants Hosp, Dept Pediat, Alpert Med Sch, Providence, RI USA

[11] Univ Utah Hlth, Dept Internal Med, Salt Lake City, UT USA

[12] Univ Utah Hlth, Dept Biomed Informat, Salt Lake City, UT USA

[13] Univ Utah, Dept Obstet & Gynecol, Salt Lake City, UT USA

[14] Univ Utah, Dept Family & Preventat Med, Div Publ Hlth, Salt Lake City, UT 84108 USA

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2023年 / 15卷 / 02期

关键词：

UNITED-STATES; PREECLAMPSIA; GENDER; ECLAMPSIA; SEX;

D O I：

10.1002/dad2.12443

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionWomen with hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular disease. Whether HDP is also associated with later-life dementia has not been fully explored. MethodsUsing the Utah Population Database, we performed an 80-year retrospective cohort study of 59,668 parous women. ResultsWomen with, versus without, HDP, had a 1.37 higher risk of all-cause dementia (95% confidence interval [CI]: 1.26, 1.50) after adjustment for maternal age at index birth, birth year, and parity. HDP was associated with a 1.64 higher risk of vascular dementia (95% CI: 1.19, 2.26) and 1.49 higher risk of other dementia (95% CI: 1.34, 1.65) but not Alzheimer's disease dementia (adjusted hazard ratio = 1.04; 95% CI: 0.87, 1.24). Gestational hypertension and preeclampsia/eclampsia showed similar increased dementia risk. Nine mid-life cardiometabolic and mental health conditions explained 61% of HDP's effect on subsequent dementia risk. DiscussionImproved HDP and mid-life care could reduce the risk of dementia.

引用

页数：10

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