Synthesis and characterization of natural fibers reinforced alginate hydrogel fibers loaded with diclofenac sodium for wound dressings

被引:33
作者
Azam, Farooq [1 ]
Ahmad, Faheem [1 ]
Ahmad, Sheraz [1 ]
Zafar, Muhammad Sohail [3 ,4 ]
Ulker, Zeynep [2 ]
机构
[1] Natl Text Univ, Sch Engn & Technol, Faisalabad 37610, Pakistan
[2] Altinbas Univ, Sch Pharm, TR-34147 Istanbul, Turkiye
[3] Taibah Univ, Coll Dent, Dept Restorat Dent, Al Madinah 41311, Saudi Arabia
[4] Riphah Int Univ, Islamic Int Dent Coll, Dept Dent Mat, Islamabad 44000, Pakistan
关键词
Composite hydrogel fiber; Natural fiber reinforcement; Wound dressing; Kapok; Hemp; NONADHERENT; NANOFIBERS; MEMBRANES; RELEASE;
D O I
10.1016/j.ijbiomac.2023.124623
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hydrogels which become increasingly important in the biomedical field are composed of a three-dimensional hydrophilic network. Pure hydrogels are usually weak and brittle; therefore, reinforcements are assimilated into the hydrogel structure to improve the mechanical strength of the hydrogels. However, even if mechanical properties are enhanced, drapability remains an issue. In that regard, natural fiber-reinforced composite hydrogel fibers for wound dressing application are investigated in this study. Kapok and hemp fibers were used as reinforcement to improve the strength of hydrogel fibers. The properties of the prepared composite hydrogel fibers were studied with Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and differential scanning calorimeter (DSC). The effect of alginate concentration and fiber weight percent on the mechanical characteristics and water absorbency was studied. Diclofenac sodium drug was loaded in the hydrogel fibers and investigated the drug release as well as antibacterial characteristics. Both fibers' reinforce-ment enhanced the strength of the alginate hydrogel fiber, but hemp reinforcement showed better mechanical properties. Kapok reinforcement resulted in a maximum tensile strength of 174 cN (1.24 % elongation) and 432 % exudate absorbency, while hemp reinforcement resulted in 185 cN (1.48 % elongation) and 435 % exudate absorbency. Statistical analysis revealed significant effects of sodium alginate concentration on tensile strength (p-value 0.042) and exudate absorbency (p-value 0.020) and of reinforcement (wt%) on exudate absorbency (p -value 0.043). Therefore, these composite hydrogel fibers with improved mechanical properties are capable of drug release and exhibit antibacterial effectiveness, making them a promising option for use as wound dressings.
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页数:10
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