Recent advances in gut microbiota-associated natural products: structures, bioactivities, and mechanisms

被引：22

作者：

Dai, Huanqin ^{[1
,2
]}

Han, Junjie ^{[1
,2
]}

Wang, Tao ^{[1
,2
]}

Yin, Wen-Bing ^{[1
,2
]}

Chen, Yihua ^{[3
]}

Liu, Hongwei ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100101, Peoples R China

来源：

NATURAL PRODUCT REPORTS | 2023年 / 40卷 / 06期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

MODULATE; OBESITY; MICE;

D O I：

10.1039/d2np00075j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Covering: 2014 to June 2022 The gut microbiota has attracted increasing attention from researchers due to its critical role in regulating human physiology and pathophysiology. Natural products (NPs) produced or transformed by gut microbes are key signalling mediators for a variety of physiological functions. On the other hand, NPs from ethnomedicines have also been found to generate health benefits through modulation of the gut microbiota. In this highlight, we review the most recent studies related to gut microbiota-derived NPs and bioactive NPs that regulate physiological and pathological processes via gut microbiota-associated mechanisms. We also outline the strategies for the discovery of gut microbiota-derived NPs and the methodologies of how to elucidate the crosstalk between bioactive NPs and the gut microbiota.

引用

页码：1078 / 1093

页数：16

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