A novel spiro-heterocycle milbemycin metabolite from a genetically engineered strain of Streptomyces bingchenggensis

被引：5

作者：

Hao, Zhi-Kui ^{[1
]}

Zhang, Shao-Yong ^{[2
]}

Qi, Huan ^{[2
]}

Xiang, Wen-Sheng ^{[3
]}

Li, Jian-Song ^{[1
]}

Wang, Ji-Dong ^{[2
]}

机构：

[1] Taizhou Vocat & Tech Coll, Sch Med & Pharmaceut Engn, Inst Appl Biotechnol, Taizhou, Peoples R China

[2] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang, Huzhou, Peoples R China

[3] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 03期

关键词：

Genetically engineered strain; milbemycin derivative; acaricidal and nematocidal activities; MACROCYCLIC LACTONES; 5-OXOMILBEMYCINS; MACROLIDE;

D O I：

10.1080/14786419.2021.1979543

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Milbemycin R, a novel spiro-heterocycle milbemycin, was obtained from the metabolites produced by the mutant strain S. bingchenggensis BCJ60B11. Its structure was determined by spectroscopic and spectrometric analyses including 1 D, 2 D NMR, IR, HR-ESI-MS data. The acaricidal and nematicidal activities of milbemycin R against Tetranychus cinnabarinus and Bursaphelenchus xylophilus were tested. Milbemycin R possessed better acaricidal activity than milbemycins A3/A4.

引用

页码：449 / 454

页数：6

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