The potential role of miRNAs in the pathogenesis of schizophrenia - A focus on signaling pathways interplay

被引：0
作者：
Zaki, Mohamed Bakr [1 ]
Abulsoud, Ahmed I. [2 ,3 ]
Ashraf, Alaa [4 ]
Abdelmaksoud, Nourhan M. [2 ]
Sallam, Al-Aliaa M. [5 ]
Aly, Shaza H. [6 ]
El-Tokhy, Fatma Sa'eed [7 ]
Rashad, Ahmed A. [4 ]
El-Dakroury, Walaa A. [7 ]
Mageed, Sherif S. Abdel [8 ]
Nomier, Yousra [9 ]
Elrebehy, Mahmoud A. [5 ]
Elshaer, Shereen Saeid [2 ,10 ]
Elballal, Mohammed S. [5 ]
Mohammed, Osama A. [11 ]
Abdel-Reheim, Mustafa Ahmed [12 ,13 ]
Doghish, Ahmed S. [5 ,14 ]
机构：
[1] Univ Sadat City, Fac Pharm, Dept Biochem, Menoufia 32897, Egypt
[2] Heliopolis Univ, Fac Pharm, Biochem Dept, Cairo 11785, Egypt
[3] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Nasr City 11231, Cairo, Egypt
[4] Badr Univ Cairo BUC, Fac Pharm, Dept Clin Pharm & Pharm Practice, Badr City 11829, Cairo, Egypt
[5] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Badr City 11829, Cairo, Egypt
[6] Badr Univ Cairo BUC, Fac Pharm, Dept Pharmacognosy, Badr City 11829, Cairo, Egypt
[7] Badr Univ Cairo BUC, Fac Pharm, Dept Pharmaceut & Ind Pharm, Badr City 11829, Cairo, Egypt
[8] Badr Univ Cairo BUC, Fac Pharm, Pharmacol & Toxicol Dept, Badr City 11829, Cairo, Egypt
[9] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Pharmacol & Clin Pharm, Muscat, Oman
[10] Al Azhar Univ, Fac Pharm Girls, Dept Biochem, Nasr City 11823, Cairo, Egypt
[11] Univ Bisha, Coll Med, Dept Pharmacol, Bisha 61922, Saudi Arabia
[12] Shaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Shaqra 11961, Saudi Arabia
[13] Beni Suef Univ, Dept Pharmacol & Toxicol, Fac Pharm, Bani Suwayf 62521, Egypt
[14] Al Azhar Univ, Fac Pharm Boys, Nasr City 11231, Cairo, Egypt
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 254卷
关键词：
Schizophrenia; MiRNA; Biomarker; Diagnosis; Dopamine system; GABA system; AUTOIMMUNE-DISEASES; NEUROTROPHIC FACTOR; VEGFR-2; INHIBITORS; PREFRONTAL CORTEX; IMMUNE-SYSTEM; RISK-FACTORS; MICRORNA; GENE; EXPRESSION; APOPTOSIS;
D O I：
10.1016/j.prp.2024.155102
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
microRNAs (miRNAs) play a crucial role in brain growth and function. Hence, research on miRNA has the potential to reveal much about the etiology of neuropsychiatric diseases. Among these, schizophrenia (SZ) is a highly intricate and destructive neuropsychiatric ailment that has been thoroughly researched in the field of miRNA. Despite being a relatively recent area of study about miRNAs and SZ, this discipline has advanced enough to justify numerous reviews that summarize the findings from the past to the present. However, most reviews cannot cover all research, thus it is necessary to synthesize the large range of publications on this topic systematically and understandably. Consequently, this review aimed to provide evidence that miRNAs play a role in the pathophysiology and progression of SZ. They have also been investigated for their potential use as biomarkers and therapeutic targets.
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页数：17
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