Comparative metabolic study of the chloroform fraction of three Cystoseira species based on UPLC/ESI/MS analysis and biological activities

被引：16
作者：
Aly, Shaza H. [1 ]
Elissawy, Ahmed M. [2 ,3 ]
El Hassab, Mahmoud A. [4 ]
Majrashi, Taghreed A. [5 ]
Hassan, Fatma E. [6 ,7 ]
Elkaeed, Eslam B. [8 ]
Eldehna, Wagdy M. [9 ]
Singab, Abdel Nasser B. [2 ,3 ]
机构：
[1] Badr Univ Cairo BUC, Dept Pharmacognosy, Badr City, Egypt
[2] Ain Shams Univ, Dept Pharmacognosy, Cairo, Egypt
[3] Ain Shams Univ, Ctr Drug Discovery Res & Dev, Cairo, Egypt
[4] King Salman Int Univ KSIU, Dept Med Chem, South Sinai, Egypt
[5] King Khalid Univ, Coll Pharm, Dept Pharmacognosy, Asir, Saudi Arabia
[6] Batterjee Med Coll, Pathol Dept, Gen Med Practice, Jeddah, Saudi Arabia
[7] Cairo Univ, Med Physiol Dept, Kasr Alainy, Giza, Egypt
[8] Almaarefa Univ, Coll Pharm, Dept Pharmaceut Sci, Riyadh, Saudi Arabia
[9] Kafrelsheikh Univ, Dept Pharmaceut Chem, Kafrelsheikh, Egypt
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2024年 / 39卷 / 01期
关键词：
Antioxidants; anti-inflammatory; antihyperglycemic; brown algae; molecular docking; PHENOLIC PROFILES; ALPHA-GLUCOSIDASE; REDUCING POWER; ANTIOXIDANT; EXTRACTS; INHIBITION; CHEMISTRY; SEAWEEDS; GENUS; ACID;
D O I：
10.1080/14756366.2023.2292482
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study aims to investigate the phytoconstituents of the chloroform fraction of three Cystoseira spp. namely C. myrica, C. trinodis, and C. tamariscifolia using UPLC/ESI/MS technique. The results revealed the identification of 19, 20 and 11 metabolites in C. myrica, C. trinodis, and C. tamariscifolia, respectively mainly terpenoids, flavonoids, phenolic acids and fatty acids. Also, an in vitro antioxidant study using FRAP and DPPH assays was conducted where the chloroform fraction of C. trinodis displayed the highest antioxidant activity in both assays, which would be attributed to its highest total phenolics and total flavonoids. Besides, the investigation of COX-1, alpha-glucosidase and alpha-amylase inhibitory activities were performed. Regarding C. trinodis, it showed the strongest inhibitory activity towards COX-1. Moreover, it showed potent inhibitory activity towards alpha-glucosidase and alpha-amylase enzymes. According to the molecular docking studies, the major compounds characterised showed efficient binding to the active sites of the target enzymes. [GRAPHICS] .
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页数：14
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