Molecular mechanisms of cellular metabolic homeostasis in stem cells

被引：20
作者：
Li, Xiaoyu [1 ,2 ,3 ]
Jiang, Ou [1 ,2 ,3 ]
Wang, Songlin [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
机构：
[1] Capital Med Univ, Salivary Gland Dis Ctr, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Key Lab Tooth Regenerat & Funct Reconstruc, Beijing Lab Oral Hlth, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Stomatol Hosp, Beijing, Peoples R China
[4] Capital Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing, Peoples R China
[5] Capital Med Univ, Beijing Friendship Hosp, Immunol Res Ctr Oral & Syst Hlth, Beijing, Peoples R China
[6] Capital Med Univ, Beijing Tiantan Hosp, Lab Oral & Gen Hlth Integrat & Translat, Beijing, Peoples R China
[7] Chinese Acad Med Sci, Res Unit Tooth Dev & Regenerat, Beijing, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ORAL SCIENCE | 2023年 / 15卷 / 01期
基金：
中国国家自然科学基金;
关键词：
FATE DECISIONS; SELF-RENEWAL; PATHWAY; DIFFERENTIATION; OXIDATION; AMPK; SENESCENCE; SURVIVAL; STAT;
D O I：
10.1038/s41368-023-00262-z
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management. In this review, we summarize the known relationship between the regulation of metabolic homeostasis and molecular pathways in stem cells. We also discuss potential targets of metabolic homeostasis in disease therapy and describe the current limitations and future directions in the development of these novel therapeutic targets.
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页数：13
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