CD44 targeted delivery of hyaluronic-acid-coated polymeric nanoparticles against colorectal cancer

被引：10
|
作者：
Phatak, Niraj [1 ]
Bhattacharya, Sankha [1 ]
Shah, Disha [1 ]
Manthalkar, Laxmi [1 ]
Sreelaya, Putrevu [1 ]
Jain, Arinjay [1 ]
机构：
[1] Deemed To Be Univ, Shri Vile Parle Kelavani Mandals Narsee Monjee Ins, Sch Pharm & Technol Management, Shirpur 425405, Maharashtra, India
来源：
NANOMEDICINE | 2023年 / 18卷 / 23期
关键词：
CD44; receptor; colorectal cancer; HCT116; hyaluronic acid; polymeric nanoparticles; sorafenib tosylate; targeted drug delivery; SORAFENIB; COMBINATION; FORMULATION;
D O I：
10.2217/nnm-2023-0145
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To develop hyaluronic acid (HA)-coated poly-lactic-co-glycolic acid (PLGA)-polysarcosine (PSAR) coupled sorafenib tosylate (SF) polymeric nanoparticles for targeted colon cancer therapy. Materials & methods: PLGA-PSAR shells were encapsulated with SF via nanoprecipitation. Interactions were examined with transmission electron microscopy, revealing formulation component interactions. Results: The optimized HA-coated polymeric nanoparticles (238.8 nm, -6.1 mV, 68.361% entrapment) displayed enhanced controlled release of SF. These formulations showed superior cytotoxicity against HCT116 cell lines compared with free drug (p < 0.05). In vivo tests on male albino Wistar rats demonstrated improved pharmacokinetics, targeting and biocompatibility. HA-coated PLGA-PSAR-coupled SF polymeric nanoparticles hold potential for effective colorectal therapy. Conclusion: Colon cancer may be precisely targeted by HA-coated PLGA-PSA-coupled SF polymeric nanoparticles.
引用
收藏
页码：1613 / 1634
页数：22
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