How to Manage Heart Failure With Preserved Ejection Fraction Practical Guidance for Clinicians

被引：37

作者：

Desai, Akshay S. ^{[1
,6
]}

Lam, Carolyn S. P. ^{[2
,3
]}

McMurray, John J. V. ^{[4
]}

Redfield, Margaret M. ^{[5
]}

机构：

[1] Brigham & Womens Hosp, Cardiovasc Div, Boston, MA USA

[2] Natl Heart Ctr, Singapore, Singapore

[3] Duke Natl Univ Singapore, Singapore, Singapore

[4] Univ Glasgow, British Heart Fdn Cardiovasc Res Ctr, Glasgow, Scotland

[5] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA

[6] Brigham & Womens Hosp, Ctr Adv Heart Dis, Cardiovasc Div, PBB-A3-AB370,75 Francis St, Boston, MA 02115 USA

来源：

JACC-HEART FAILURE | 2023年 / 11卷 / 06期

基金：

英国医学研究理事会;

关键词：

chronic heart failure; heart failure with preserved ejection fraction; NATRIURETIC PEPTIDE LEVELS; ATRIAL-FIBRILLATION; CARDIOVASCULAR EVENTS; NONCARDIAC COMORBIDITIES; CATHETER ABLATION; OBESE PHENOTYPE; KIDNEY-DISEASE; SPIRONOLACTONE; MORTALITY; OUTCOMES;

D O I：

10.1016/j.jchf.2023.03.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although patients with heart failure with preserved ejection fraction (HFpEF) (left ventricular ejection fraction $50%) comprise nearly half of those with chronic heart failure, evidence-based treatment options for this population have historically been limited. Recently, however, emerging data from prospective, randomized trials enrolling patients with HFpEF have greatly altered the range of pharmacologic options to modify disease progression in selected patients with HFpEF. In the context of this evolving landscape, clinicians are increasingly in need of practical guidance regarding the best approach to management of this growing population. In this review, the authors build on the recently published heart failure guidelines by integrating contemporary data from recent randomized trials to provide a contemporary framework for diagnosis and evidence-based treatment of patients with HFpEF. Where gaps in knowledge persist, the authors provide "best available" data from post hoc analyses of clinical trials or data from observational studies to guide management until more definitive studies are available. (J Am Coll Cardiol HF 2023;11:619-636) & COPY; 2023 by the American College of Cardiology Foundation.

引用

页码：619 / 636

页数：18

共 119 条

[91] Phenomapping for Novel Classification of Heart Failure With Preserved Ejection Fraction [J].

Shah, Sanjiv J. ;

Katz, Daniel H. ;

Selvaraj, Senthil ;

Burke, Michael A. ;

Yancy, Clyde W. ;

Gheorghiade, Mihai ;

Bonow, Robert O. ;

Huang, Chiang-Ching ;

Deo, Rahul C. .

CIRCULATION, 2015, 131 (03) :269-+

[92] Baseline Characteristics of Patients in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial [J].

Shah, Sanjiv J. ;

Heitner, John F. ;

Sweitzer, Nancy K. ;

Anand, Inder S. ;

Kim, Hae-Young ;

Harty, Brian ;

Boineau, Robin ;

Clausell, Nadine ;

Desai, Akshay S. ;

Diaz, Rafael ;

Fleg, Jerome L. ;

Gordeev, Ivan ;

Lewis, Eldrin F. ;

Markov, Valetin ;

O'Meara, Eileen ;

Kobulia, Bondo ;

Shaburishvili, Tamaz ;

Solomon, Scott D. ;

Pitt, Bertram ;

Pfeffer, Marc A. ;

Li, Rebecca .

CIRCULATION-HEART FAILURE, 2013, 6 (02) :184-192

[93] Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials A position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association [J].

Skyler, Jay S. ;

Bergenstal, Richard ;

Bonow, Robert O. ;

Buse, John ;

Deedwania, Prakash ;

Gale, Edwin A. M. ;

Howard, Barbara V. ;

Kirkman, M. Sue ;

Kosiborod, Mikhail ;

Reaven, Peter ;

Sherwin, Robert S. .

DIABETES CARE, 2009, 32 (01) :187-192

[94] Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction [J].

Solomon, S. D. ;

McMurray, J. J., V ;

Claggett, B. ;

de Boer, R. A. ;

DeMets, D. ;

Hernandez, A. F. ;

Inzucchi, S. E. ;

Kosiborod, M. N. ;

Lam, C. S. P. ;

Martinez, F. ;

Shah, S. J. ;

Desai, A. S. ;

Jhund, P. S. ;

Belohlavek, J. ;

Chiang, C-E ;

Borleffs, C. J. W. ;

Comin-Colet, J. ;

Dobreanu, D. ;

Drozdz, J. ;

Fang, J. C. ;

Alcocer-Gamba, M. A. ;

Al Habeeb, W. ;

Han, Y. ;

Cabrera Honorio, J. W. ;

Janssens, S. P. ;

Katova, T. ;

Kitakaze, M. ;

Merkely, B. ;

O'Meara, E. ;

Saraiva, J. F. K. ;

Tereshchenko, S. N. ;

Thierer, J. ;

Vaduganathan, M. ;

Vardeny, O. ;

Verma, S. ;

Pham, V. N. ;

Wilderang, U. ;

Zaozerska, N. ;

Bachus, E. ;

Lindholm, D. ;

Petersson, M. ;

Langkilde, A. M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, :1089-1098

[95] Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction [J].

Solomon, S. D. ;

McMurray, J. J. V. ;

Anand, I. S. ;

Ge, J. ;

Lam, C. S. P. ;

Maggioni, A. P. ;

Martinez, F. ;

Packer, M. ;

Pfeffer, M. A. ;

Pieske, B. ;

Redfield, M. M. ;

Rouleau, J. L. ;

van Veldhuisen, D. J. ;

Zannad, F. ;

Zile, M. R. ;

Desai, A. S. ;

Claggett, B. ;

Jhund, P. S. ;

Boytsov, S. A. ;

Comin-Colet, J. ;

Cleland, J. ;

Dungen, H. -D. ;

Goncalvesova, E. ;

Katova, T. ;

Kerr Saraiva, J. F. ;

Lelonek, M. ;

Merkely, B. ;

Senni, M. ;

Shah, S. J. ;

Zhou, J. ;

Rizkala, A. R. ;

Gong, J. ;

Shi, V. C. ;

Lefkowitz, M. P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (17) :1609-1620

[96] Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure [J].

Solomon, Scott D. ;

Vaduganathan, Muthiah ;

Claggett, Brian L. ;

Packer, Milton ;

Zile, Michael ;

Swedberg, Karl ;

Rouleau, Jean ;

Pfeffer, Marc A. ;

Desai, Akshay ;

Lund, Lars H. ;

Kober, Lars ;

Anand, Inder ;

Sweitzer, Nancy ;

Linssen, Gerard ;

Merkely, Bela ;

Arango, Juan Luis ;

Vinereanu, Dragos ;

Chen, Chen-Huan ;

Senni, Michele ;

Sibulo, Antonio ;

Boytsov, Sergey ;

Shi, Victor ;

Rizkala, Adel ;

Lefkowitz, Martin ;

McMurray, John J., V .

CIRCULATION, 2020, 141 (05) :352-361

[97] Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial [J].

Solomon, Scott D. ;

Rizkala, Adel R. ;

Lefkowitz, Martin P. ;

Shi, Victor C. ;

Gong, JianJian ;

Anavekar, Nagesh ;

Anker, Stefan D. ;

Arango, Juan L. ;

Arenas, Jose L. ;

Atar, Dan ;

Ben-Gal, Turia ;

Boytsov, Sergey A. ;

Chen, Chen-Huan ;

Chopra, Vijay K. ;

Cleland, John ;

Comin-Colet, Josep ;

Duengen, Hans-Dirk ;

Echeverria Correa, Luis E. ;

Filippatos, Gerasimos ;

Flammer, Andreas J. ;

Galinier, Michel ;

Godoy, Armando ;

Goncalvesova, Eva ;

Janssens, Stefan ;

Katova, Tzvetana ;

Kober, Lars ;

Lelonek, Malgorzata ;

Linssen, Gerard ;

Lund, Lars H. ;

O'Meara, Eileen ;

Merkely, Bela ;

Milicic, Davor ;

Oh, Byung-Hee ;

Perrone, Sergio V. ;

Ranjith, Naresh ;

Saito, Yoshihiko ;

Saraiva, Jose F. ;

Shah, Sanjiv ;

Seferovic, Petar M. ;

Senni, Michele ;

Sibulo, Antonio S., Jr. ;

Sim, David ;

Sweitzer, Nancy K. ;

Taurio, Jyrki ;

Vinereanu, Dragos ;

Vrtovec, Bojan ;

Widimsky, Jiri ;

Yilmaz, Mehmet B. ;

Zhou, Jingmin ;

Zweiker, Robert .

CIRCULATION-HEART FAILURE, 2018, 11 (07)

[98] Influence of ejection fraction on outcomes and efficacy of spironolactone in patients with heart failure with preserved ejection fraction [J].

Solomon, Scott D. ;

Claggett, Brian ;

Lewis, Eldrin F. ;

Desai, Akshay ;

Anand, Inder ;

Sweitzer, Nancy K. ;

O'Meara, Eileen ;

Shah, Sanjiv J. ;

McKinlay, Sonja ;

Fleg, Jerome L. ;

Sopko, George ;

Pitt, Bertram ;

Pfeffer, Marc A. .

EUROPEAN HEART JOURNAL, 2016, 37 (05) :455-462

[99] Effect of candesartan on cause-specific mortality in heart failure patients - The Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM) program [J].

Solomon, SD ;

Wang, DL ;

Finn, P ;

Skali, H ;

Zornoff, L ;

McMurray, JJV ;

Swedberg, K ;

Yusuf, S ;

Granger, CB ;

Michelson, EL ;

Pocock, S ;

Pfeffer, MA .

CIRCULATION, 2004, 110 (15) :2180-2183

[100] Coronary microvascular dysfunction and future risk of heart failure with preserved ejection fraction [J].

Taqueti, Viviany R. ;

Solomon, Scott D. ;

Shah, Amil M. ;

Desai, Akshay S. ;

Groarke, John D. ;

Osborne, Michael T. ;

Hainer, Jon ;

Bibbo, Courtney F. ;

Dorbala, Sharmila ;

Blankstein, Ron ;

Di Carli, Marcelo F. .

EUROPEAN HEART JOURNAL, 2018, 39 (10) :840-849

← 3 4 5 6 7 8 9 10 11 12 →