Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation

被引：17

作者：

Aoi, Wataru ^{[1
]}

Inoue, Ryo ^{[1
,2
]}

Mizushima, Katsura ^{[2
,3
]}

Honda, Akira ^{[3
,4
]}

Bjornholm, Marie ^{[4
,5
]}

Takagi, Tomohisa ^{[6
,7
]}

Naito, Yuji ^{[3
]}

机构：

[1] Kyoto Prefectural Univ, Grad Sch Life & Environm Sci, Div Appl Life Sci, Kyoto 6068522, Japan

[2] Setsunan Univ, Fac Agr, Dept Appl Biol Sci, Lab Anim Sci, Osaka 5730101, Japan

[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Human Immunol & Nutr Sci, Kyoto 6028566, Japan

[4] Tokyo Med Univ, Ibaraki Med Ctr, Gastroenterol, Ibaraki 3000395, Japan

[5] Karolinska Inst, Dept Mol Med & Surg, S-17176 Stockholm, Sweden

[6] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Mol Gastroenterol & Hepatol, Kyoto 6028566, Japan

[7] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Med Innovat & Translat Med Sci, Kyoto 6028566, Japan

来源：

ISCIENCE | 2023年 / 26卷 / 03期

基金：

日本学术振兴会;

关键词：

Habitual exercise; diet -induced metabolic; skeletal muscle; Altered microbiota; PROTEIN-KINASE-C; GUT MICROBIOTA; MITOCHONDRIAL BIOGENESIS; SEDENTARY BEHAVIOR; PHYSICAL-ACTIVITY; ADIPOSE-TISSUE; AMP-KINASE; DIET; ACTIVATION; HEALTH;

D O I：

10.1016/j.isci.2023.106251

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Habitual exercise alters the intestinal microbiota composition, which may mediate its systemic benefits. We examined whether transplanting fecal microbiota from trained mice improved skeletal muscle metabolism in high-fat diet (HFD)-fed mice. Fecal samples from sedentary and exercise-trained mice were gavage-fed to germ-free mice. After receiving fecal samples from trained donor mice for 1 week, recipient mice had elevated levels of AMP-activated protein kinase (AMPK) and insulin growth factor-1 in skeletal muscle. In plasma, bile acid (BA) deconjugation was found to be promoted in recipients transplanted with feces from trained donor mice; free-form BAs also induced more AMPK signaling and glucose uptake than tauro-conjugated BAs. The transplantation of exercise-acclimated fecal microbiota improved glucose tolerance after 8 weeks of HFD administration. Intestinal microbiota may mediate exercise-induced metabolic improvements in mice by modifying circulating BAs. Our findings provide insights into the prevention and treatment of metabolic diseases.

引用

页数：20

共 69 条

[21] Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction [J].